Ivabradine HCl

Catalog No.S2086 Batch:S208601

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Technical Data

Formula

C27H36N2O5.HCl

Molecular Weight 505.05 CAS No. 148849-67-6
Solubility (25°C)* In vitro DMSO 101 mg/mL (199.98 mM)
Ethanol 101 mg/mL (199.98 mM)
Water 82 mg/mL (162.36 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Ivabradine HCl (S 16257-2,S-18982 D6 hydrochloride), a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.
Targets
Adrenergic Receptor [1]

Protocol (from reference)

Selleck's Ivabradine HCl has been cited by 2 publications

Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch [ Cell Rep, 2022, 38(10):110468] PubMed: 35263588
Increased HCN Channel Activity in the Gasserian Ganglion Contributes to Trigeminal Neuropathic Pain [ J Pain, 2018, 19(6):626-634] PubMed: 29366880

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.