HC-030031
Catalog No.S2918 Synonyms: TOSLAB 829227
Molecular Weight(MW): 355.39
HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.
Purity & Quality Control
Choose Selective Calcium Channel Inhibitors
Biological Activity
| Description | HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively. | |||||||||||||||||||||||
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| In vitro |
HC-030031 is a substituted theophylline derivative. Potent and selective TRPA1 inhibitor. HC-030031 can block both inward and outward currents elicited by AITC or formalin rapidly and reversibly and also blocks the activation of TRPA1 by N-methylmaleimide and by electrophillic prostaglandins. It does not block currents mediated by TRPV1, TRPV3, TRPV4 hERG, or NaV1.2 channels. [1] |
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| Cell Data |
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| In vivo | HC-030031 can be delivered to animals orally, by inhalation, or by injection. Oral administration (100 mg/kg) of HC-030031 significantly reversed mechanical hypersensitivity in rat models of chronic inflammatory or neuropathic pain, while local injection (100 μg) into inflamed mouse hind paws attenuated mechanical, but not heat, hypersensitivity. [2] [3] |
Protocol
| Animal Research:[2] |
+ Expand
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Solubility (25°C)
| In vitro | DMSO | 32 mg/mL (90.04 mM) |
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| Water | Insoluble | |
| Ethanol | Insoluble | |
| In vivo | Add solvents individually and in order: 0.5% methylcellulose |
30 mg/mL |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 355.39 |
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| Formula | C18H21N5O3 |
| CAS No. | 349085-38-7 |
| Storage | powder |
| Synonyms | TOSLAB 829227 |
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