Home Transmembrane Transporters TRP Channel antagonist RN-1734

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RN-1734 TRP Channel antagonist

Cat.No.S2650

RN-1734 (TRPV4 Antagonist I) is a selective transient receptor potential vanilloid 4 (TRPV4) antagonist with IC50 of 2.3 μM, 5.9 μM and 3.2 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. This compound alleviates demyelination and inhibits glial activation and the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.
RN-1734 TRP Channel antagonist Chemical Structure

Chemical Structure

Molecular Weight: 353.31

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Quality Control

Batch: S265001 DMSO]71 mg/mL]false]Ethanol]71 mg/mL]false]Water]Insoluble]false Purity: 99.94%
99.94

Solubility

In vitro
Batch:

DMSO : 71 mg/mL (200.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 71 mg/mL

Water : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 353.31 Formula

C14H22Cl2N2O2S

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 946387-07-1 -- Storage of Stock Solutions

Synonyms TRPV4 Antagonist I Smiles CC(C)NCCN(C(C)C)S(=O)(=O)C1=C(C=C(C=C1)Cl)Cl

Mechanism of Action

Targets/IC50/Ki
TNF-α
IL-1β
hTRPV4
(Cell-free assay)
2.3 μM
rTRPV4
(Cell-free assay)
3.2 μM
mTRPV4
(Cell-free assay)
5.9 μM
References

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