HDAC Inhibitors

HDAC Inhibitors (25)
water-soluble

Cat.No.	Product Name	Information	Product Citations
S1053	Entinostat (MS-275, SNDX-275)	MS-275 is an HDAC inhibitor of HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, respectively.	Nat Biotechnol, 2011, 29(3), 255-265 Proc Natl Acad Sci U S A, 2011, 108(49):19629-34 Circ Res, 2012, 110(5):739-48
S1047	Vorinostat (SAHA)	Vorinostat (suberoylanilide hydroxamic acid, SAHA, Zolinza) is an HDAC inhibitor with IC50 of ~10 nM.	Nature, 2011, 471(7337):235-9 Nat Biotechnol, 2011, 29(3), 255-265 J Exp Med, 2012, 209(1):35-50
S1030	Panobinostat (LBH589)	LBH589 (Panobinostat) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM and 20 nM in MOLT-4 and Reh cells, respectively.	Nat Biotechnol, 2011, 29(3), 255-265 Blood, 2012, 119(6):1450-8 Acta Neuropathol, 2011, 122(5):637-50
S3020	Romidepsin (FK228 ,depsipeptide)	Romidepsin (FK228, FR901228, depsipeptide, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.
S1045	Trichostatin A (TSA)	Trichostatin A (TSA) is an HDAC inhibitor with IC50 of ~1.8 nM.	Epigenetics, 2012, 7(10), 1161-1172
S8049	Tubastatin A	Tubastatin A is a potent and selective inhibitor of HDAC6 with IC50 of 15 nM.
S4909	Apicidin (OSI-2040)	Apicidin is a potent HDAC inhibitor with IC50 of 0.7 nM.
S1122	Mocetinostat (MGCD0103)	MGCD0103 (Mocetinostat) is a potent HDAC inhibitor for HDAC1, HDAC2 and HDAC3 with IC50 of 0.15 μM, 0.29 μM and 1.66 μM, respectively.	Nat Struct Mol Biol, 2013, 20(3):317-25 Circ Res, 2012, 110(5):739-48 Oncogene, 2011, 30(27), 3062-3072
S2627	Tubastatin A HCl	Tubastatin A is a potent HDAC6 inhibitor with IC50 of 15 nM.
S8001	Rocilinostat (ACY-1215)	Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM.
S2779	M344	M344 is a potent HDAC inhibitor with IC50 of 100 nM.
S2759	PI3K/HDAC InhibitorⅠ	PI3K/HDAC Inhibitor I is a dual PI3K and HDAC inhibitor for PI3Kɑ, HDAC1, HDAC2, HDAC3 and HDAC10 with IC50 of 19 nM, 1.7 nM, 5 nM, 1.8 nM and 2.8 nM, respectively.
S2012	PCI-34051	PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM.
S2818	CI994 (Tacedinaline)	CI994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM.
S2244	AR-42 (HDAC-42)	AR-42 (HDAC-42, OSU-HDAC42) is a pan-HDAC inhibitor with IC50 30 nM.
S2170	ITF2357 (Givinostat)	ITF2357 (Givinostat) is a potent inhibitor of HDAC with IC50 of 7.5-16 nM.
S1515	SB939 (Pracinostat)	SB939 is a potent HDAC inhibitor with IC50 of 40-140 nM.	Antimicrob Agents Chemother, 2012, 56(7), 3849-3856
S1484	MC1568	MC1568 is a selective HDAC inhibitor with IC50 of 220 nM.	Proc Natl Acad Sci U S A, 2012, 109(34):E2284-93 J Biol Chem, 2011, 286(27), 23842-23851 J Biol Chem, 2011, 286(18), 16101-16108
S1422	Droxinostat	Droxinostat (CMH, 5809354) is a selective inhibitor of HDAC3, HDAC6 and HDAC8 with IC50 of 16.9 μM, 2.47μM and 1.46 μM, respectively.	Nat Struct Mol Biol, 2013, 20(3):317-25
S1194	CUDC-101	CUDC-101 is a potent multi-target inhibitor targeting HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, respectively.
S1168	Valproic acid sodium salt (Sodium valproate)	Valproic acid sodium salt (Sodium valproate) is a HDAC inhibitor with IC50 of 0.4 mM and also inhibits GABA-transaminase or succinic semialdehyde dehydrogenase.
S1096	JNJ-26481585	JNJ-26481585 (Quisinostat) is an HDAC inhibitor for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11 with IC50 of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM and 0.37 nM, respectively.
S1095	LAQ824 (NVP-LAQ824, Dacinostat)	LAQ824 (NVP-LAQ824) is a novel HDAC inhibitor with IC50 of 32 nM.	Nat Biotechnol, 2011, 29(3), 255-265 Diabetologia, 2012, 55(9):2421-31 Mol Pain, 2010, 6, 51
S1090	PCI-24781	PCI-24781 (CRA-024781) is a novel broad spectrum HDAC inhibitor targeting HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with K_i of 7 nM, 19 nM, 8.2 nM, 17 nM, 280 nM, 24 nM, respectively.	Nat Biotechnol, 2011, 29(3), 255-265
S1085	Belinostat (PXD101)	Belinostat (PXD101) is a novel HDAC inhibitor with IC50 of 27 nM in HeLa cell extracts.	Nat Biotechnol, 2011, 29(3), 255-265 Breast Cancer Res Treat, 2011, 131(3), 777-789 PLoS One, 2011, 6(2), e17138

Inhibitory Selectivity
Solubility

Cat.No.	Product Name	Solubility (25°C)
Cat.No.	Product Name	Water	DMSO	Ethanol
S1053	Entinostat (MS-275, SNDX-275)	<1 mg/mL	75 mg/mL	<1 mg/mL
S1047	Vorinostat (SAHA)	<1 mg/mL	53 mg/mL	3 mg/mL
S1030	Panobinostat (LBH589)	<1 mg/mL	70 mg/mL	<1 mg/mL
S3020	Romidepsin (FK228 ,depsipeptide)	<1 mg/mL	10 mg/mL	<1 mg/mL
S1045	Trichostatin A (TSA)	<1 mg/mL	23 mg/mL	<1 mg/mL
S1122	Mocetinostat (MGCD0103)	<1 mg/mL	13 mg/mL	<1 mg/mL
S2627	Tubastatin A HCl	<1 mg/mL	74 mg/mL	<1 mg/mL
S8001	Rocilinostat (ACY-1215)	<1 mg/mL	87 mg/mL	<1 mg/mL
S2779	M344	<1 mg/mL	62 mg/mL	4 mg/mL
S2759	PI3K/HDAC InhibitorⅠ	<1 mg/mL	102 mg/mL	<1 mg/mL
S2012	PCI-34051	<1 mg/mL	59 mg/mL	<1 mg/mL
S2818	CI994 (Tacedinaline)	<1 mg/mL	≥54 mg/mL	<1 mg/mL
S2244	AR-42 (HDAC-42)	<1 mg/mL	63 mg/mL	63 mg/mL
S2170	ITF2357 (Givinostat)	<1 mg/mL	95 mg/mL	3 mg/mL
S1515	SB939 (Pracinostat)	<1 mg/mL	72 mg/mL	27 mg/mL
S1484	MC1568	<1 mg/mL	13 mg/mL	<1 mg/mL
S1422	Droxinostat	<1 mg/mL	49 mg/mL	49 mg/mL
S1194	CUDC-101	<1 mg/mL	20 mg/mL	<1 mg/mL
S1168	Valproic acid sodium salt (Sodium valproate)	33 mg/mL	33 mg/mL	33 mg/mL
S1096	JNJ-26481585	<1 mg/mL	79 mg/mL	<1 mg/mL
S1095	LAQ824 (NVP-LAQ824, Dacinostat)	<1 mg/mL	76 mg/mL	<1 mg/mL
S1090	PCI-24781	<1 mg/mL	80 mg/mL	<1 mg/mL
S1085	Belinostat (PXD101)	<1 mg/mL	64 mg/mL	<1 mg/mL

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HDAC Inhibitors

HDAC Inhibitors (25)
water-soluble

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HDAC Inhibitors

HDAC Inhibitors (25)water-soluble

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HDAC Inhibitors (25)
water-soluble