DNA alkylator

Isoform-selective Products

DNA alkylator Products

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  • DNA alkylator Inhibitors (3)
  • DNA alkylator Activator (1)
  • DNA alkylator Modulators (2)
  • New DNA alkylator Products
Catalog No. Product Name Information Product Use Citations Product Validations
S1224 Oxaliplatin Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Mol Cancer, 2024, 23(1):23
Gastroenterology, 2024, S0016-5085(24)00062-3
NPJ Precis Oncol, 2024, 8(1):52
S1215 Carboplatin Carboplatin, a derivative of CDDP, is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death and interfers with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks. Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Clin Cancer Res, 2024, 30(1):187-197
Int J Mol Sci, 2024, 25(2)886
Nat Commun, 2023, 14(1):4057
S2057 Cyclophosphamide Monohydrate Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.
BMC Cancer, 2024, 24(1):185
EMBO Mol Med, 2023, 15(12):e18199
Int J Mol Sci, 2022, 23(7)3834
S1312 STZ (Streptozotocin) STZ (Streptozotocin) is a glucosamine-nitrosourea compound derived from Streptomyces achromogenes, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis. Solutions are unstable and should be fresh-prepared.
J Endocr Soc, 2024, 8(2):bvad176
Front Bioeng Biotechnol, 2023, 11:1052607
Nat Med, 2022, 10.1038/s41591-021-01645-7
S1692 Busulfan Busulfan is a cell cycle non-specific alkylating antineoplastic agent. It causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase activity. It also induces apoptosis. It is an immunosuppressive and myeloablative chemotherapeutic agent.
Nat Commun, 2022, 13(1):6110
Blood Cancer Discov, 2022, 3(2):154-169
iScience, 2022, 25(10):105182
S8266 Melphalan Melphalan (Alkeran, Sarcolysin, L-PAM) is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Heliyon, 2024, 10(1):e23165
Cell Rep Med, 2023, 4(6):101091
Cell Rep, 2023, 42(8):112925
S1302 Ifosfamide Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
Comput Struct Biotechnol J, 2023, 21:3827-3840
Nat Commun, 2022, 13(1):6308
Cells, 2022, 11(14)2164
S1278 Altretamine Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 34(6):1911-1918
S8056 Lomeguatrib Lomeguatrib (PaTrin-2) is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.
Neurooncol Adv, 2024, 6(1):vdad165
Pharmaceuticals (Basel), 2021, 14(2)107
Cancer Sci, 2020, 112(1):133-143
S3658 O6-Benzylguanine O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
Nat Commun, 2023, 14(1):5913
Nat Commun, 2023, 14(1):5913
Neuro Oncol, 2021, 23(6):920-931
E0609 Methyl methanesulfonate Methyl methanesulfonate (MMS), a DNA alkylating agent, modifies both guanine (to 7-methylguanine) and adenine (to 3-methlyladenine) to cause base mispairing and replication blocks, respectively.
Cell Rep, 2024, 43(2):113779
J Transl Med, 2023, 21(1):183
S8880 Lobaplatin (D-19466) Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Biochem Pharmacol, 2020, 12:114023
S6984 Dianhydrogalactitol (VAL-083) Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity.
S4447 Pipobroman Pipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity.
S6958 Treosulfan

Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.

S7829 Tretazicar (CB1954) Tretazicar (CB1954) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.
S5840 Palifosfamide Palifosfamide (ZIO-201, Isophosphamide mustard) is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.
S1215 Carboplatin Carboplatin, a derivative of CDDP, is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death and interfers with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks. Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Clin Cancer Res, 2024, 30(1):187-197
Int J Mol Sci, 2024, 25(2)886
Nat Commun, 2023, 14(1):4057
S8056 Lomeguatrib Lomeguatrib (PaTrin-2) is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.
Neurooncol Adv, 2024, 6(1):vdad165
Pharmaceuticals (Basel), 2021, 14(2)107
Cancer Sci, 2020, 112(1):133-143
S3658 O6-Benzylguanine O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
Nat Commun, 2023, 14(1):5913
Nat Commun, 2023, 14(1):5913
Neuro Oncol, 2021, 23(6):920-931
S1302 Ifosfamide Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
Comput Struct Biotechnol J, 2023, 21:3827-3840
Nat Commun, 2022, 13(1):6308
Cells, 2022, 11(14)2164
S4447 Pipobroman Pipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity.
S6958 Treosulfan

Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.

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