MTH1

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Catalog No. Information Product Use Citations Product Validations
S7505

(S)-crizotinib

(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.

S7631

TH287

TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.

S7632

TH588

TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM.

Catalog No. Information Product Use Citations Product Validations
S7505

(S)-crizotinib

(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.

S7631

TH287

TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.

S7632

TH588

TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM.