MTH1

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S7505 (S)-crizotinib <1 mg/mL 42 mg/mL 22 mg/mL
S7631 TH287 <1 mg/mL 53 mg/mL 10 mg/mL
S7632 TH588 <1 mg/mL 20 mg/mL 1 mg/mL
Catalog No. Information Product Use Citations Product Validations
S7505

(S)-crizotinib

(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.

S7631

TH287

TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.

S7632

TH588

TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.