Home Cell Cycle CDK

CDK Inhibitors

CDKs (Cyclin-dependent kinases), a small heteromeric serine/threonine kinases with 34-40kDa, plays a key role in regulating cell cycle progression and transcriptional regulation. A CDK has to bind to a cyclin, a family of proteins that control the progression of cells, to gain its kinase activity.

Other Cell Cycle Related Inhibitors

ROCK Wee1 Aurora Kinase Chk PLK APC MPS1 Rho Myc DYRK

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S1116 PD-0332991 (Palbociclib) Hydrochloride Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.
Nature, 2025, 10.1038/s41586-025-09328-w
Cancer Discov, 2025, 10.1158/2159-8290.CD-24-1378
Nat Commun, 2025, 16(1):6677
Verified customer review of PD-0332991 (Palbociclib) Hydrochloride
S5716 Abemaciclib (LY2835219) Abemaciclib is a cell cycle inhibitor selective for CDK4/6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively.
Nat Genet, 2025, 57(6):1452-1462
Nat Commun, 2025, 16(1):4254
Mol Cell, 2025, S1097-2765(25)00042-5
S8903 AS2863619 AS2863619 is a small-molecule cyclin-dependent kinase CDK8/19 inhibitor with IC50 of 0.6099 nM and 4.277 nM, respectively. AS2863619 is a potent Foxp3 inducer in Tconv cells.
Science, 2022, 378(6620):eabn5647
S7440 LEE011 (Ribociclib) Ribociclib is an orally available, and highly specific inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM. Phase 3.
Nat Commun, 2025, 16(1):2132
Cell Rep Med, 2025, S2666-3791(25)00231-9
EMBO J, 2025, 10.1038/s44318-025-00554-6
Verified customer review of LEE011 (Ribociclib)
S7747 Ro-3306 RO-3306 is an ATP-competitive, and selective CDK1 inhibitor with Ki of 20 nM, >15-fold selectivity against a diverse panel of human kinases. RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis.
Nat Commun, 2025, 16(1):7898
Nat Commun, 2025, 16(1):6439
Nucleic Acids Res, 2025, 53(21)gkaf1179
Verified customer review of Ro-3306
S4482 Palbociclib (PD-0332991) Palbociclib (PD 0332991) is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) and Cdk6 with IC50 of 11 nM and 16 nM, respectively.This product has poor solubility, animal in vivo experiments are available, cell experiments please choose carefully!
Signal Transduct Target Ther, 2025, 10(1):363
Drug Resist Updat, 2025, 78:101161
Nat Commun, 2025, 16(1):7622
S8840 SEL120 (SEL120-34A) hydrochloride SEL120 (SEL120-34, SEL120-34A) is a novel inhibitor of Cyclin-dependent kinase 8 (CDK8) with IC50 values of 4.4 nM and 10.4 nM for CDK8/Cyclin C and CDK19/CyclinC respectively.
Cell Rep Med, 2025, S2666-3791(25)00231-9
Nature, 2024, 10.1038/s41586-024-08314-y
Endocrinology, 2024, 165(10)bqae114
E1854 INX-315 INX-315 is an orally active and selective inhibitor of CDK2 that induces cell cycle arrest in the G1 phase. It exhibits an IC50 value of 2.3 nM in intracellular NanoBRET assay, respectively. It displays a 50-fold increased CDK2 selectivity compared to CDK1. INX-315 decreases the phosphorylation of CDK2 substrates and suppresses tumor growth in xenograft mouse models in a dose-dependent manner.
S7158 LY2835219 (Abemaciclib) Mesylate Abemaciclib mesylate is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.
Cell Rep Med, 2025, S2666-3791(25)00231-9
EBioMedicine, 2025, 118:105828
NPJ Breast Cancer, 2025, 11(1):39
Verified customer review of LY2835219 (Abemaciclib) Mesylate
S9878 Tagtociclib (PF-07104091) Tagtociclib (PF-07104091) inhibits CDK2, which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.
JCI Insight, 2025, e189901
Nat Commun, 2024, 15(1):9181

Signaling Pathway Map