Cyclin-dependent kinase

Cat.No.	Product Name	Added

S1524	AT7519	Oct 2010
AT7519 is a kinase inhibitor with IC50 of 0.19, 0.044, 0.51, 0.067, 0.66 and 0.018 μM for CDK1/cyclinB, CDK2/CyclinA, CDK2/Cyclin E, CDk4/CyclinD1, CDK6/Cyclin D3, CDk5/p35.

S2621	AZD5438	Jun 2011
AZD5438 is a potent cyclin-dependent kinase (cdk) 1, 2 and 9 inhibitor with IC50 of 16, 6 and 20 nM, respectively.

S1572	BS-181	Nov 2010
BS-181 is a selective cyclin-dependent kinase inhibitor with an IC50 of 21 nM for the inhibition of CDK-activating kinase.

S1230	Flavopiridol (Alvocidib)	May 2010
Flavopiridol (Alvocidib) is a pan-cdk inhibitor. Flavopiridol is a potent inhibitor of CDKs 1, 2 and 4 in cell-free assays (IC50 in the region of 100 nM) and tumour cell growth in vitro (typical IC50 in the region of 100 nM). Flavopiridol inhibited rhabdoid cell growth (IC50 of 200nmol/L).

S2679	Flavopiridol hydrochloride	Aug 2011
Flavopiridol hydrochloride is a pan-cdk inhibitor.

S2386	Indirubin	Feb 2011
Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of median 75 and 28M, respectively.

S1249	JNJ-7706621	May 2010
JNJ-7706621 is a dual cyclin-dependent kinases and aurora kinases inhibitor with IC50 of 9 and 11 nM for CDK1/Cyclin B and aurora-A, respectively.

S1116	PD 0332991	Sep 2009
PD 0332991 is a CDK inhibitor with an IC50 of 0.011 μM for Cdk4 and IC50 of 0.016 μM for Cdk6.

S2742	PHA-767491	Dec 2011
PHA-767491 is a potent, ATP-competitive dual cdk7/cdk9 inhibitor with IC50 of 10 and 34 nM for cdk7 and CDK9, respectively.

S1487	PHA-793887	Sep 2010
PHA-793887 is a novel pan-cdk inhibitor, including cdk1, cdk2, cdk4, cdk5, cdk7, and cdk9 with IC50 in the 5 to 140 nM range.

S2688	R547	Aug 2011
R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases with a Ki of median 2 nM for CDK1/cyclin B, CDK2/cyclin E, and CDK4/cyclin D1.

S1153	Roscovitine (Seliciclib)	Feb 2010
Roscovitine also known as CYC202 & Seliciclib. Roscovitine with purity >99% & solubility DMSO is available.

S1145	SNS-032 (BMS-387032)	Jan 2010
SNS-032 (BMS-387032) is a potent and selective cyclin-dependent kinases (CDK) 9, 7 and 2 inhibitor with IC50 of 4, 62 and 38 nM for CDK9, CDK2/cyclin A and CDK7/Cyclin H.