CDK Chemicals

Cat.No.	Product Name	Information
E4760	YJ1206	YJ1206 is an orally bioavailable, highly specific and potent degrader of CDK12/13 with an IC50 of 12.55 nM in VCaP cells. It increases DNA damage, induces apoptosis, and demonstrates robust anti-tumor activity in vivo.
E6400^New	BSJ-5-63	BSJ-5-63 is a potent PROTAC degrader of CDK12, CDK7, CDK9. BSJ-5-63 decreases the protein expression of CDK12, CDK7, CDK9, RNAPII, Cyclin K, while also suppressing the mRNA expression of BRCA1 and BRCA2. BSJ-5-63 demonstrates anticancer properties and has the potential for the research of prostate cancer.
E5876^New	LL-K12-18	LL-K12-18 is a potent dual-site molecular glue that enhances CDK12-DDB1 complex formation, promoting cyclin K degradation with an EC50 of 0.37 nM. It also demonstrates strong inhibition of gene transcription and anti-proliferative effects in tumor cells, exhibiting significant potential in cancer research.