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TBK1

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Cat.No. Product Name Information Product Use Citations Product Validations
S8922 TBK1/IKKε-IN-5 TBK1/IKKε-IN-5 (compound 1) is a dual inhibitor of TANK-binding kinase 1 (TBK1) and IκB kinase-ε (IKKε/IKK-i) with IC50 of 1.0 nM and 5.6 nM for TBK1 and IKKε, respectively. TBK1/IKKε inhibition enhances response to PD-1 blockade, which effectively predicts tumor response in vivo.
Autophagy, 2025, 1-23.
Cancer Res, 2025, 10.1158/0008-5472.CAN-25-1791
Sci Adv, 2024, 10(6):eadk2285
S8872 GSK8612 GSK8612 is a highly potent and selective inhibitor for TBK1 (Tank-binding Kinase-1) with pKd of 8.0. Within 10-fold affinity with respect to TBK1, no off-targets of this compound could be identified.
Nature, 2025, 10.1038/s41586-025-08938-8
Nat Cell Biol, 2025, 27(8):1272-1287
Autophagy, 2025, 1-23.
S6386 MRT67307

MRT67307 (IKKε/TBK1 Inhibitor II) inhibits IKKε and TBK1 with IC50 values of 160 nM and 19 nM at 0.1 mM ATP in vitro, but does not inhibit IKKα or IKKβ even at 10 μM. This compound also is a highly potent ULK1 and ULK2 inhibitor with IC50s of 45 and 38 nM, respectively. It can blocks autophagy in cells.
Front Pharmacol, 2022, 13:924523
Microbiol Spectr, 2022, e0219321
S1274 BX-795 BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1. BX-795 also is a potent TBK1 inhibitor that blocks both TBK1 and IKKε with IC 50 values of 6 nM and 41 nM, respectively.
Cancer Res, 2025, 10.1158/0008-5472.CAN-25-1791
Cell Rep, 2025, 44(7):115972
EMBO J, 2024, 10.1038/s44318-024-00244-9
Verified customer review of BX-795
S7948 MRT67307 HCl MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibits ULK1 and ULK2 and blocks autophagy.
EMBO Rep, 2025, 10.1038/s44319-025-00444-2
EMBO J, 2024, 10.1038/s44318-024-00244-9
mBio, 2023, 10.1128/mbio.02506-23
Verified customer review of MRT67307 HCl
S3648 Amlexanox Amlexanox is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε.
Biomed Pharmacother, 2025, 186:117991
Cell Death Discov, 2025, 11(1):286
Sci Adv, 2025, 11(4):eadq2395
S8935 BAY-985 BAY-985 is a potent and highly selective TBK1/IKKε inhibitor. This compound shows high potency toward TBK1 (IC50 = 2 nM, low ATP assay; 30 nM, high ATP assay) and IKKε(IC50 = 2 nM), as well as high potency in the mechanistic pIRF3 assay (IC50 = 74 nM), and an antiproliferative effect on SK-MEL-2 cells (IC50 = 900 nM).
Nat Commun, 2023, 14(1):1399
Nat Commun, 2023, 14(1):1399
Mol Cancer, 2022, 21(1):97
S0425 TBK1/IKKε-IN-2 TBK1/IKKε-IN-2 (Ikk epsilon-in-1, IKKε-IN-1, MDK10496) is a dual inhibitor of TBK1 and IKKε.
Int J Mol Sci, 2022, 23(23)15000