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Aquaporin

Other Transmembrane Transporters Related Inhibitors

CFTR CRM1 Calcium Channel Proton Pump P-gp Sodium Channel ATPase Potassium Channel CD markers GLUT

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S3585 Z433927330 Z433927330 is a potent and efficacious inhibitor of mouse AQP7 (Aquaporin-7) with an IC50 of ~0.2 µM. This compound also inhibits mouse AQP3 (Aquaporin-3) and mouse AQP9 (Aquaporin-9) with IC50s of ~0.7 µM and ~1.1 µM, respectively.
Genes (Basel), 2025, 16(7)730
E5834New DFP00173 DFP00173 is a selective and potent inhibitor of Aquaporin-3 (AQP3), it inhibits mouse and human AQP3 with an IC50 of ∼0.1 μM–0.4 μM. It demonstrates potential for treating human disorders of water retention.
S0158 TGN020 TGN-020 (compound 9) is a selective aquaporin 4 (AQP4) inhibitor with IC50 of 3.1 μM that may have an inhibitory effect on diabetic retinal edema.
S3272 Steviol (Hydroxydehydrostevic acid) Steviol (Hydroxydehydrostevic acid, Hydroxy Dehydrostevic Acid, NSC 226902), a major metabolite of the sweetening compound stevioside, inhibits CFTR activity, reduces AQP2 expression and promotes AQP2 degradation.