CAS No. 199596-24-2
Batch:
Purity:99.84
Chemical Structure
Check the
Z-JIB-04 (NSC 693627)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-chloro-N-[(Z)-[phenyl(pyridin-2-yl)methylidene]amino]pyridin-2-amine | |
|---|---|---|
| CAS Number | 199596-24-2 | |
| Molecular Formula |
C17H13ClN4 |
|
| Molecular Weight (MW) | 308.76 | |
| SMILES | C1=CC=C(C=C1)C(=NNC2=NC=C(C=C2)Cl)C3=CC=CC=N3 | |
| InChIKey | YHHFKWKMXWRVTJ-XLNRJJMWSA-N |
Z-JIB-04 is the Z-isomer of JIB-04, a pan-selective Jumonji histone demethylase inhibitor that targets JARID1A, JMJD2D, JMJD2E, JMJD2B, JMJD2A, JMJD3, and JMJD2C. Inhibiting these demethylases alters histone methylation, disrupting transcriptional pathways and suppressing cancer cell growth.
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
8 mg/mL
(25.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.