Home Protein Tyrosine Kinase VEGFR inhibitor Vorolanib

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Vorolanib VEGFR inhibitor

Cat.No.S6843

Vorolanib (X-82,CM082) is an oral, multikinase, dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) with antiangiogenic and antineoplastic activities.
Vorolanib VEGFR inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 439.4

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Quality Control

Batch: S684301 DMSO]89 mg/mL]false]Ethanol]5 mg/mL]false]Water]˂1 mg/mL]false Purity: 99.83%
99.83

Solubility

In vitro
Batch:

DMSO : 89 mg/mL (202.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 5 mg/mL

Water : ˂1 mg/mL

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Mass Concentration Volume Molecular Weight
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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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%
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 439.4 Formula

C23H26FN5O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1013920-15-4 -- Storage of Stock Solutions

Synonyms X-82,CM082 SMILES CC1=C(NC(=C1C(=O)NC2CCN(C2)C(=O)N(C)C)C)C=C3C4=C(C=CC(=C4)F)NC3=O

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC50/Ki
VEGFR
PDGFR
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-07-09)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07047001 ACTIVE_NOT_RECRUITING
Renal Cell Carcinoma (RCC); Adjuvant
Dong Wen
 2025-04-24 PHASE2
NCT07165418 NOT_YET_RECRUITING
Renal Cell Carcinoma (RCC)
Peking University Cancer Hospital & Institute
 2025-09-25 PHASE3
NCT06577961 NOT_YET_RECRUITING
Kidney Cancer; RCC; Renal Cell Carcinoma
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
 2024-08-31 PHASE1; PHASE2
NCT06585878 NOT_YET_RECRUITING
Renal Cell Carcinoma; RCC; Kidney Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
 2024-09-01
NCT07386158 RECRUITING
Vorolanib; Clear Cell Renal Cell Carcinoma (ccRCC); Neoadjuvant Therapy
Sun Yat-sen University
 2025-07-10 PHASE2
NCT06728852 RECRUITING
Advanced Non-small Cell Lung Cancer (NSCLC); Recurrent or Metastatic Lung Cancer; Third-line and Beyond Therapy; Angiogenesis Inhibition in Oncology
Li-kun Chen
 2024-12-01 PHASE2

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