Tenofovir alafenamide hemifumarate

Catalog No.S4427 Batch:S442701

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Technical Data

Formula

C46H62N12O14P2

Molecular Weight 1069 CAS No. 1392275-56-7
Solubility (25°C)* In vitro DMSO 100 mg/mL (93.54 mM)
Ethanol 100 mg/mL (93.54 mM)
Water 50 mg/mL (46.77 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
Targets
reverse transcriptase [1]

Protocol (from reference)

Selleck's Tenofovir alafenamide hemifumarate has been cited by 1 publication

How to Control HTLV-1-Associated Diseases: Preventing de Novo Cellular Infection Using Antiviral Therapy [ Front Microbiol, 2018, 9:278] PubMed: 29593659

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.