Rolapitant

Catalog No.S5476 Synonyms: SCH-619734

Rolapitant Chemical Structure

Molecular Weight(MW): 500.48

Rolapitant is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit.

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Purity & Quality Control

Choose Selective Substance P Inhibitors

Biological Activity

Description Rolapitant is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit.

Protocol

References

Solubility (25°C)

Chemical Information

Molecular Weight 500.48
Formula

C25H26F6N2O2

CAS No. 552292-08-7
Storage powder
in solvent
Synonyms SCH-619734

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02991456 Recruiting Chemo-radiation Induced Nausea and Vomiting Duke University|Tesaro Inc. October 9 2017 Phase 2
NCT02991456 Recruiting Chemo-radiation Induced Nausea and Vomiting Duke University|Tesaro Inc. October 9 2017 Phase 2
NCT02732015 Recruiting Sarcoma M.D. Anderson Cancer Center|TerSera October 2016 Phase 2
NCT02732015 Recruiting Sarcoma M.D. Anderson Cancer Center|TerSera October 2016 Phase 2
NCT02434861 Completed Chemotherapy-induced Nausea and Vomiting Tesaro Inc. May 2015 Phase 1
NCT02434861 Completed Chemotherapy-induced Nausea and Vomiting Tesaro Inc. May 2015 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID