Regorafenib Hydrochloride

Catalog No.S4947 Synonyms: Stivarga, BAY 73-4506 hydrochloride

For research use only.

Regorafenib (Stivarga, BAY 73-4506) Hydrochloride is a multi-target inhibitor for VEGFR1, Murine VEGFR2/3, PDGFRβ, Kit (c-Kit), RET (c-RET) and Raf-1 with IC50 of 13 nM, 4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.

Regorafenib Hydrochloride Chemical Structure

CAS No. 835621-07-3

Selleck's Regorafenib Hydrochloride has been cited by 16 publications

Purity & Quality Control

Choose Selective VEGFR Inhibitors

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Biological Activity

Description Regorafenib (Stivarga, BAY 73-4506) Hydrochloride is a multi-target inhibitor for VEGFR1, Murine VEGFR2/3, PDGFRβ, Kit (c-Kit), RET (c-RET) and Raf-1 with IC50 of 13 nM, 4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.
Targets
RET [1]
(Cell-free assay)
Raf-1 [1]
(Cell-free assay)
Murine VEGFR2 [1]
(Cell-free assay)
Kit [1]
(Cell-free assay)
VEGFR1 [1]
(Cell-free assay)
Click to View More Targets
1.5 nM 2.5 nM 4.2 nM 7 nM 13 nM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(192.57 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 519.28
Formula

C21H16Cl2F4N4O3

CAS No. 835621-07-3
Storage 3 years -20°C powder
2 years -80°C in solvent

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03386825 Completed Drug: Regorafenib (Stivarga BAY73-4506) Colorectal Neoplasms Bayer January 31 2018 --
NCT01959269 Completed Drug: Regorafenib (Stivarga BAY 73-4506) Colorectal Neoplasm Bayer October 31 2013 --
NCT01002378 Completed Drug: Regorafenib (Stivarga BAY73-4506) Dietary Fats|Pharmacokinetics Bayer October 2009 Phase 1
NCT01003015 Completed Drug: BAY73-4506 Carcinoma Hepatocellular Bayer September 2009 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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