Home PI3K/Akt/mTOR PDPK1 activator PS-48

research use only

PS-48 PDPK1 activator

Cat.No.S7586

PS-48 is an allosteric activator of phosphoinositide-dependent protein kinase-1 (PDK1).
PS-48 PDPK1 activator Chemical Structure

Chemical Structure

Molecular Weight: 286.75

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S758601 DMSO]57 mg/mL]false]Ethanol]57 mg/mL]false]Water]Insoluble]false Purity: 99.73%
99.73

Chemical Information, Storage & Stability

Molecular Weight 286.75 Formula

C17H15ClO2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1180676-32-7 -- Storage of Stock Solutions

Synonyms N/A Smiles C1=CC=C(C=C1)C(=CC(=O)O)CCC2=CC=C(C=C2)Cl

Solubility

In vitro
Batch:

DMSO : 57 mg/mL (198.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 57 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
PDPK1 [1]
In vitro

The PDK1 agonist PS48 is able to promote the osteogenic ability of MC3T3-E1 cells treated with dexamethasone. The protein levels of p-AKT and p-mTOR are increased in MC3T3-E1 cells treated with dexamethasone after PS48 treatment.[2]
In vivo

In vivo, the PDK1 agonist PS48 can maintain the bone mass of mice treated with dexamethasone.[2]
References

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.