CAS No. 1180676-32-7
Batch:
Purity:99.73
Chemical Structure
Check the
PS-48
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid | |
|---|---|---|
| CAS Number | 1180676-32-7 | |
| Molecular Formula |
C17H15ClO2 |
|
| Molecular Weight (MW) | 286.75 | |
| SMILES | C1=CC=C(C=C1)C(=CC(=O)O)CCC2=CC=C(C=C2)Cl | |
| InChIKey | LLJYFDRQFPQGNY-QINSGFPZSA-N |
PS-48 is a selective, small-molecule allosteric activator of phosphoinositide-dependent protein kinase-1 (PDK1) that targets the regulatory PIF-binding pocket. By binding to this allosteric site, PS-48 stimulates PDK1 kinase activity independently of phosphoinositide binding. This selective activation promotes downstream phosphorylation and activation of target kinases within the PI3K/AKT pathway, driving cellular signaling and survival. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(198.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 57 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.