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Povidone iodine Hydrotropic Agents inhibitor

Name: Povidone iodine
Brand: Selleck Chemicals
SKU: S4678
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4678

Povidone iodine (Betadine, PVP iodine, PVP-I, Isodine) is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. This compound displays excellent antibacterial activity against MRSA and MSSA strains with MICs of 31.25 mg/L and 7.82 mg/L, respectively. It is used as a topical antiseptic in surgery and for skin and mucous membrane infections, as well as as an aerosol.

Chemical Structure

Molecular Weight:

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S467801 DMSO]28 mg/mL]false]Water]28 mg/mL]false]Ethanol]28 mg/mL]false Purity: 99%

Related Targets	Bacterial Antibiotics Anti-infection Fungal Antiviral COVID-19 Parasite Reverse Transcriptase HIV HCV Protease SARS-CoV HIV Protease Influenza Virus β-lactamase Integrase HBV CMV Neuraminidase HCV HSV RSV Enterovirus Thioredoxin Reductase 3C-Like Protease Ribosomal Peptidyl Transferase HPV
Related Products	PEG300 CMC-Na SBE-β-CD Tween 80 PEG400 Pluronic F-68

Chemical Information, Storage & Stability

Molecular Weight		Formula	(C₆H₉NO)x.xI₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	25655-41-8	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Betadine, PVP iodine, PVP-I, Isodine			Smiles	C=CN1CCCC1=O.II

Solubility

In vitro
Batch:

DMSO : 28 mg/mL ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 28 mg/mL

Ethanol : 28 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro	Exposure to PVP-I, of which concentrations are even lower than those used clinically, causes toxicity in epithelial cells^[2].
In vivo	Povidone-iodine is a broad spectrum antiseptic for topical application in the treatment and prevention of infection in wounds, using the antiseptic properties of iodine. A study investigating its use in defective tissue in neural structures reveals that Myelin changes are absent or minimal in all cases of the control group but are present as markedly increased myelin degeneration in nearly all cases in this compound group. Axonal degeneration and hypoxic neuronal damage are absent in the control group, whereas they are marked in half of this chemical group. No statistically significant differences are established in Schwann cell proliferation, venous congestion, and lymphocytic proliferation between the two groups^[1].
References	https://pubmed.ncbi.nlm.nih.gov/22885709/ https://pubmed.ncbi.nlm.nih.gov/24219135/ https://pubmed.ncbi.nlm.nih.gov/28736269/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05745467	Withdrawn	SARS-CoV-2 Acute Respiratory Disease	University of Iowa\|3M	July 3 2024	Phase 4
NCT05696132	Not yet recruiting	MRSA	Nantes University Hospital	February 2023	Phase 2
NCT05704959	Active not recruiting	HEALTHY INDIVIDUALS	Hasan Kalyoncu University	March 15 2022	Not Applicable
NCT05077592	Unknown status	Surgical Site Infection\|Surgical Wound Infection	Ain Shams University	September 18 2021	Phase 4

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