Povidone iodine

Catalog No.S4678 Synonyms: Betadine, PVP iodine, PVP-I, Isodine

For research use only.

Povidone iodine (Betadine, PVP iodine, PVP-I, Isodine) is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It is used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol.

Povidone iodine Chemical Structure

CAS No. 25655-41-8

Purity & Quality Control

Choose Selective Hydrotropic Agents Inhibitors

Biological Activity

Description Povidone iodine (Betadine, PVP iodine, PVP-I, Isodine) is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It is used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol.
In vitro

Exposure to PVP-I, of which concentrations are even lower than those used clinically, causes toxicity in epithelial cells[2].

In vivo Povidone-iodine is a broad spectrum antiseptic for topical application in the treatment and prevention of infection in wounds, using the antiseptic properties of iodine. A study investigating its use in defective tissue in neural structures reveals that Myelin changes are absent or minimal in all cases of the control group but are present as markedly increased myelin degeneration in nearly all cases in the PVP-I group. Axonal degeneration and hypoxic neuronal damage are absent in the control group, whereas they are marked in half of the PVP-I group. No statistically significant differences are established in Schwann cell proliferation, venous congestion, and lymphocytic proliferation between the two groups[1].

Protocol (from reference)

Cell Research:[2]
  • Cell lines: HeLa cells
  • Concentrations: 0.01-1000 μM
  • Incubation Time: 1 or 2 days
  • Method: One day after seeding, wells are exposed to PVP-I (0.01 to 1000 μM), which has been diluted with DMEM containing 10% FBS. Plates are further cultured for 1 or 2 days at 37℃ in a 5% CO2 incubator. The cell incubation time of 1 or 2 days is determined based on data regarding the onset time of iododerma and nephropathy pathogenesis.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 28 mg/mL
Water 28 mg/mL
Ethanol '28 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight
Formula

(C6H9NO)x.xI2

CAS No. 25655-41-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C=CN1CCCC1=O.II

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05077592 Recruiting Drug: 10% Povidone Iodine Surgical Site Infection|Surgical Wound Infection Ain Shams University September 18 2021 Phase 4
NCT04658355 Not yet recruiting Other: Chlorhexidine Gluconate|Other: Povidone-iodine Vaginal Flora Imbalance University of Arizona December 15 2020 Not Applicable
NCT04364802 Recruiting Drug: Povidone-Iodine Nasal Spray and Gargle COVID-19|SARS-CoV 2 Alexandra Kejner|University of Kentucky April 29 2020 Phase 2
NCT04041856 Unknown status Drug: Povidone Ophthalmic Adenoviral Keratoconjunctivitis Farabi Eye Hospital August 23 2019 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Povidone iodine | Povidone iodine ic50 | Povidone iodine price | Povidone iodine cost | Povidone iodine solubility dmso | Povidone iodine purchase | Povidone iodine manufacturer | Povidone iodine research buy | Povidone iodine order | Povidone iodine mouse | Povidone iodine chemical structure | Povidone iodine mw | Povidone iodine molecular weight | Povidone iodine datasheet | Povidone iodine supplier | Povidone iodine in vitro | Povidone iodine cell line | Povidone iodine concentration | Povidone iodine nmr