Piperazine Erastin

Piperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death.

Piperazine Erastin Chemical Structure

Piperazine Erastin Chemical Structure

CAS: 1538593-71-3

Purity & Quality Control

Batch: E106301 DMSO] 100 mg/mL] false] Ethanol] 100 mg/mL] false] Water] Insoluble] false Purity: 98.83%
98.83

Piperazine Erastin Related Products

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Biological Activity

Description Piperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death.
In vitro
In vitro

Piperazine Erastin, an analogue of Erastin, induces ferroptosis of cancer cells and upregulates PTGS2 in BJeLR cells that is suppressed when cotreatment of vitamin E.[1]

In Vivo
In vivo

Piperazine Erastin shows efficacy in preventing HT-1080 tumor formation in a mouse xenograft model, through upregulation of Ptgs2, and robust upregulation of the p21 gene, a biomarker for p53 activation induced by doxorubicin-mediated DNA damage.[1]

Chemical Information & Solubility

Molecular Weight 645.19 Formula

C35H41ClN6O4

CAS No. 1538593-71-3 SDF --
Smiles CC(C)OC1=CC=C(CN2CCNCC2)C=C1N3C(=NC4=C(C=CC=C4)C3=O)CN5CCN(CC5)C(=O)COC6=CC=C(Cl)C=C6
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (154.99 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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