CAS No. 3032970-74-1
Chemical Structure
Check the
PB94
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-(1-adamantylmethyl)-1-[[4-(hydroxycarbamoyl)-3-methoxyphenyl]methyl]indole-5-carboxamide | |
|---|---|---|
| CAS Number | 3032970-74-1 | |
| Molecular Formula |
C29H33N3O4 |
|
| Molecular Weight (MW) | 487.59 | |
| InChIKey | JJMWRKOHPNUEJN-UHFFFAOYSA-N |
Biological Activity
PB94 is a potent and selective inhibitor of histone deacetylase 11 (HDAC11). By inhibiting HDAC11 enzymatic activity, it modulates epigenetic gene regulation and histone acetylation pathways. This inhibition alters neural signaling cascades, contributing to the attenuation of neuropathic pain responses in vivo. Additionally, radiolabeled formulations of this compound demonstrate significant central nervous system permeability, enabling non-invasive imaging and translational evaluation of HDAC11 expression in brain tissue.
How to Prepare Stock Solution?
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Note: Technical data last updated: Sep 1, 2026.