Home Microbiology Fungal inhibitor Luliconazole

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Luliconazole Fungal inhibitor

Cat.No.S4258

Luliconazole(NND 502) is a broad-spectrum antifungal drug.
Luliconazole Fungal inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 354.28

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Quality Control

Batch: S425801 DMSO]71 mg/mL]false]Ethanol]5 mg/mL]false]Water]Insoluble]false Purity: 99.99%
99.99

Solubility

In vitro
Batch:

DMSO : 71 mg/mL (200.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 354.28 Formula

C14H9Cl2N3S2

 Storage (From the date of receipt)
CAS No. 187164-19-8 Download SDF Storage of Stock Solutions

Synonyms NND 502 Smiles C1C(SC(=C(C#N)N2C=CN=C2)S1)C3=C(C=C(C=C3)Cl)Cl

Mechanism of Action

In vitro

Luliconazole inhibits growth of all filamentous fungi except zygomycetes at low concentrations (MIC, ≦0.004–0.125 µg/ml), with dermatophytes being most susceptible (MIC, ≦0.004–0.008 µg/ml). This compound demonstrates greater potency against Trichophyton spp. (MIC range:

In vivo

Luliconazole (1% cream) treatment produces a clinical effi cacy somewhat below terbinafine with 50.8% in a guinea pig model of dermatophytosis. This compound treated guinea pigs have hairs covered with amorphous debris and a small number of conidia are detected. The improved efficacy of this chemical over Lanoconazole is likely due to it being strictly an R-enantiomer while lanoconazole is a racemic mixture.

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05110638 Active not recruiting
Onychomycosis of Toenail
SATO Pharmaceutical Co. Ltd.
 September 13 2021 Phase 1
NCT02767947 Completed
Tinea Corporis
Bausch Health Americas Inc.
 February 8 2016 Phase 4
NCT02767271 Completed
Tinea Pedis|Tinea Cruris
Bausch Health Americas Inc.
 December 2 2015 Phase 4
NCT02394340 Completed
Tinea Pedis|Tinea Cruris
Bausch & Lomb Incorporated|Bausch Health Americas Inc.
 February 3 2015 Phase 4

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