Name: Ledipasvir acetone
Brand: Selleck Chemicals
SKU: S4434
Rating: 5 (1 reviews)

Ledipasvir (GS-5885) acetone is the active ingredient of Ledipasvir. Ledipasvir is a potent, oral active inhibitor of the hepatitis C virus (HCV) NS5A with EC50 of 31 pM and 4 pM against GT1a and GT1b replicon, respectively.

Ledipasvir acetone Chemical Structure

CAS: 1441674-54-9

Purity & Quality Control

Batch: S443401 DMSO] 100 mg/mL] false] Ethanol] 100 mg/mL] false] Water] Insoluble] false Purity: 99.76%

99.76

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Choose Selective HCV Inhibitors

Biological Activity

Description

Ledipasvir (GS-5885) acetone is the active ingredient of Ledipasvir. Ledipasvir is a potent, oral active inhibitor of the hepatitis C virus (HCV) NS5A with EC50 of 31 pM and 4 pM against GT1a and GT1b replicon, respectively.

Targets

GT1b replicon ^[1] (Cell-free assay)	GT1a replicon ^[1] (Cell-free assay)
4 pM(EC50)	31 pM(EC50)

In vitro
In vitro	Ledipasvir acetone induces HCV clearance, inhibits STAT3 protein levels and restores HNF4A expression.^[1]
Cell Research	Cell lines	highly permissive transformed liver Huh-7.5 cell line
	Concentrations	--
	Incubation Time	9 days
	Method	-- (Data sourced from selleck products)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT03903185	Completed	Hepatitis C Chronic\|Hematologic Malignancy	Ain Shams University\|Cairo University	March 1 2019	Phase 1\|Phase 2
NCT03639207	Withdrawn	Hepatitis C Virus	National Cancer Institute (NCI)\|National Institutes of Health Clinical Center (CC)	June 15 2018	--
NCT05091008	Completed	Hepatitis C Chronic	Mansoura University Children Hospital	March 1 2018	Phase 2

References

[1] Aydin Y, et al. Cancers (Basel). 2019 Sep 20;11(10):1407.

Chemical Information & Solubility

Molecular Weight	947.08	Formula	C₅₂H₆₀F₂N₈O₇
CAS No.	1441674-54-9	SDF	--
Smiles	COC(=O)NC(C(C)C)C(=O)N1CC2(CC2)CC1C3=NC=C([NH]3)C4=CC5=C(C=C4)C6=C(C=C(C=C6)C7=CC8=C(C=C7)N=C([NH]8)C9C%10CCC(C%10)N9C(=O)C(NC(=O)OC)C(C)C)C5(F)F.CC(C)=O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (105.58 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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