CAS No. 1441674-54-9

Batch: Purity:99.76
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Ledipasvir acetone Chemical Structure
Chemical Structure
Check the Ledipasvir acetone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl N-[(2S)-1-[(6S)-6-[5-[9,9-difluoro-7-[2-[(1R,3S,4S)-2-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-2-azabicyclo[2.2.1]heptan-3-yl]-3H-benzimidazol-5-yl]fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]heptan-5-yl]-3-methyl-1-oxobutan-2-yl]carbamate;propan-2-one
CAS Number 1441674-54-9
Molecular Formula

C52H60F2N8O7
Molecular Weight (MW) 947.08
SMILES COC(=O)NC(C(C)C)C(=O)N1CC2(CC2)CC1C3=NC=C([NH]3)C4=CC5=C(C=C4)C6=C(C=C(C=C6)C7=CC8=C(C=C7)N=C([NH]8)C9C%10CCC(C%10)N9C(=O)C(NC(=O)OC)C(C)C)C5(F)F.CC(C)=O
InChIKey FJPWYOHJVGOKNZ-NDANSHMASA-N

Ordering Information

Biological Activity

Ledipasvir acetone is an orally active hepatitis C virus (HCV) NS5A inhibitor that exhibits potent antiviral activity against GT1a replicon (EC50 of 31 pM) and GT1b replicon (EC50 of. By targeting the NS5A protein, it disrupts HCV RNA replication and assembly, thereby suppressing viral replication complexes and preventing infectious virion production in host cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (105.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.