Home Epigenetics Histone Demethylase inhibitor L-2-Hydroxyglutaric acid disodium

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L-2-Hydroxyglutaric acid disodium Histone Demethylase inhibitor

Cat.No.S1325

L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. This compound is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.

L-2-Hydroxyglutaric acid disodium Histone Demethylase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 192.08

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S132501 Water]38 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.88%
99.88

Chemical Information, Storage & Stability

Molecular Weight 192.08 Formula
C5H6Na2O5
 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 63512-50-5 -- Storage of Stock Solutions

Synonyms (S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG Smiles [Na+].[Na+].OC(CCC([O-])=O)C([O-])=O

Solubility

In vitro
Batch:

Water : 38 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
Histone Demethylase [1]
Mi-CK [2]
(Cell-free assay)
2.52 mM(Km)
Mi-CK [2]
(Cell-free assay)
11.13 mM(Ki)
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06343974 Not yet recruiting
Pregnancy in Diabetic|Diabetes Mellitus Type 1
Turku University Hospital
 June 1 2024 --
NCT06127823 Recruiting
GDM|Gestational Diabetes|Nutritional and Metabolic Diseases|Nutrition Therapy|Medical Nutrition Therapy
Steno Diabetes Center Copenhagen|Herlev Hospital|Rigshospitalet Denmark
 January 3 2024 Not Applicable
NCT06218771 Recruiting
Acute Myeloid Leukemia|Myelodysplastic Syndromes
Chia Tai Tianqing Pharmaceutical Group Co. Ltd.
 July 10 2023 Phase 1|Phase 2
NCT05430204 Active not recruiting
Gestational Diabetes
The University of Texas Health Science Center Houston|DexCom Inc.
 March 7 2023 Not Applicable

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