L-2-Hydroxyglutaric acid disodium

Catalog No.S1325 Synonyms: (S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG

For research use only.

L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.

L-2-Hydroxyglutaric acid disodium Chemical Structure

CAS No. 63512-50-5

Purity & Quality Control

Choose Selective Histone Demethylase Inhibitors

Biological Activity

Description

L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.

Targets
Histone Demethylase [1] Mi-CK [2]
(Cell-free assay)
Mi-CK [2]
(Cell-free assay)
2.52 mM(Km) 11.13 mM(Ki)

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 192.08
Formula
C5H6Na2O5
CAS No. 63512-50-5
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04169243 Not yet recruiting Behavioral: New Nordic Diet|Other: Control Gestational Diabetes Mellitus Göteborg University|Swedish Council for Working Life and Social Research September 2022 Not Applicable
NCT05430204 Not yet recruiting Device: Group 1: one-hour GCT|Device: Group 2: CGM placement Gestational Diabetes The University of Texas Health Science Center Houston|DexCom Inc. August 1 2022 Not Applicable
NCT05436119 Not yet recruiting Dietary Supplement: GrowBaby Premature Birth|Pre-Eclampsia|Small for Gestational Age Infant GrowBaby Life Project|Metagenics Inc.|OmegaQuant LLC July 2022 --
NCT04334083 Recruiting Behavioral: Comparison of biomarkers of stress Heart Rate Variability University Hospital Clermont-Ferrand February 17 2022 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy L-2-Hydroxyglutaric acid disodium | L-2-Hydroxyglutaric acid disodium supplier | purchase L-2-Hydroxyglutaric acid disodium | L-2-Hydroxyglutaric acid disodium cost | L-2-Hydroxyglutaric acid disodium manufacturer | order L-2-Hydroxyglutaric acid disodium | L-2-Hydroxyglutaric acid disodium distributor