L-2-Hydroxyglutaric acid disodium

For research use only.

Catalog No.S1325 Synonyms: (S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG

L-2-Hydroxyglutaric acid disodium Chemical Structure

CAS No. 63512-50-5

L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.

Purity & Quality Control

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Biological Activity

Description

L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.

Targets
Histone Demethylase [1]
()
Mi-CK [2]
(Cell-free assay)
Mi-CK [2]
(Cell-free assay)
2.52 mM(Km) 11.13 mM(Ki)

Protocol

Solubility (25°C)

In vitro Water 38 mg/mL (197.83 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 192.08
Formula
C5H6Na2O5
CAS No. 63512-50-5
Storage powder
in solvent
Synonyms (S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04169243 Not yet recruiting Behavioral: New Nordic Diet|Other: Control Gestational Diabetes Mellitus Göteborg University|Swedish Council for Working Life and Social Research October 2021 Not Applicable
NCT04959838 Not yet recruiting Behavioral: Impact of prolonged work Stress|Heart Rate Variability University Hospital Clermont-Ferrand|University Clermont Auvergne (UCA) Clermont-Ferrand France|LaPSCO laboratory UMR CNRS 6024 Clermont-Ferrand France July 2021 Not Applicable
NCT04672031 Recruiting Other: Glycemic Targets Diabetes Mellitus in Pregnancy|Diabetes Gestational|Diabetes Mellitus Type 2 Richard H. Lee|University of Southern California July 8 2021 Not Applicable
NCT04906473 Not yet recruiting Drug: KY100001 Advanced Solid Tumor Kunming Pharmaceuticals Inc. July 31 2021 Phase 1
NCT04860336 Recruiting Other: Observational Gestational Diabetes|Pregnancy Related Northwestern University|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Yale University|Women and Infants Hospital of Rhode Island|University of Pittsburgh|Massachusetts General Hospital|Tufts Medical Center|Columbia University|Kaiser Permanente April 1 2021 --
NCT04520971 Recruiting Device: 780G|Device: standard of care Type1 Diabetes Universitaire Ziekenhuizen Leuven|University Hospital Ghent|Universitair Ziekenhuis Brussel|University Hospital Antwerp|Imelda Hospital Bonheiden|AZ Sint-Jan AV|AZ Delta|Onze Lieve Vrouw Hospital|General Hospital Groeninge|AZ Nikolaas January 15 2021 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Histone Demethylase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID