Name: L-2-Hydroxyglutaric acid disodium
Brand: Selleck Chemicals
SKU: S1325
Rating: 5 (1 reviews)

L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.

L-2-Hydroxyglutaric acid disodium Chemical Structure

CAS: 63512-50-5

Selleck's L-2-Hydroxyglutaric acid disodium has been cited by 1 publication

Purity & Quality Control

Batch: S132501 Water] 38 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.88%

99.88

L-2-Hydroxyglutaric acid disodium Related Products

Related Targets	KDM1 KDM2 KDM3 KDM4 KDM5 KDM6	Click to Expand
Related Compound Libraries	Kinase Inhibitor Library FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Bioactive Compound Library-Ⅱ	Click to Expand

Signaling Pathway

Histone Demethylase Signaling Pathway

Choose Selective Histone Demethylase Inhibitors

Biological Activity

Description

L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.

Targets

Histone Demethylase ^[1]	Mi-CK ^[2] (Cell-free assay)	Mi-CK ^[2] (Cell-free assay)
	2.52 mM(Km)	11.13 mM(Ki)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06127823	Recruiting	GDM\|Gestational Diabetes\|Nutritional and Metabolic Diseases\|Nutrition Therapy\|Medical Nutrition Therapy	Steno Diabetes Center Copenhagen\|Herlev Hospital\|Rigshospitalet Denmark	January 3 2024	Not Applicable
NCT05430204	Recruiting	Gestational Diabetes	The University of Texas Health Science Center Houston\|DexCom Inc.	March 7 2023	Not Applicable
NCT05744856	Recruiting	GDM	Thai Binh University of Medicine and Pharmacy\|University of Copenhagen\|University of Southern Denmark	January 16 2023	Not Applicable
NCT04169243	Recruiting	Gestational Diabetes Mellitus	Göteborg University\|Swedish Council for Working Life and Social Research	November 1 2022	Not Applicable
NCT05578690	Recruiting	Overweight and Obesity\|Pregnancy Related	Steno Diabetes Center Copenhagen\|University of Copenhagen	October 26 2022	Not Applicable

References

Chemical Information & Solubility

Molecular Weight	192.08	Formula	C₅H₆Na₂O₅
CAS No.	63512-50-5	SDF	--
Smiles	[Na+].[Na+].OC(CCC([O-])=O)C([O-])=O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

Water : 38 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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