L-2-Hydroxyglutaric acid disodium

For research use only.

Catalog No.S1325 Synonyms: (S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG

L-2-Hydroxyglutaric acid disodium Chemical Structure

CAS No. 63512-50-5

L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.

Size Price Stock Quantity  
USD 97 In stock
USD 289 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective Histone Demethylase Inhibitors

Biological Activity

Description

L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.

Targets
Histone Demethylase [1]
()
Mi-CK [2]
(Cell-free assay)
Mi-CK [2]
(Cell-free assay)
2.52 mM(Km) 11.13 mM(Ki)

Protocol

Solubility (25°C)

In vitro Water 38 mg/mL (197.83 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 192.08
Formula
C5H6Na2O5
CAS No. 63512-50-5
Storage powder
in solvent
Synonyms (S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04520971 Not yet recruiting Device: 780G|Device: standard of care Type1 Diabetes Universitaire Ziekenhuizen Leuven|University Hospital Ghent|Universitair Ziekenhuis Brussel|University Hospital Antwerp|Imelda Hospital Bonheiden|AZ Sint-Jan AV|AZ Delta|Onze Lieve Vrouw Hospital|General Hospital Groeninge|AZ Nikolaas January 2021 Not Applicable
NCT04672031 Not yet recruiting Other: Glycemic Targets Diabetes Mellitus in Pregnancy|Diabetes Gestational|Diabetes Mellitus Type 2 Richard H. Lee|University of Southern California January 2021 Not Applicable
NCT04666818 Completed Device: Use of Flash Glucose Monitoring Diabetes Mellitus in Pregnancy University of Catania November 26 2020 --
NCT04481607 Recruiting Drug: TQB3454 Advanced Solid Tumor or Hematologic Tumor Chia Tai Tianqing Pharmaceutical Group Co. Ltd. August 24 2020 Phase 1
NCT04334083 Not yet recruiting Behavioral: Comparison of biomarkers of stress Heart Rate Variability University Hospital Clermont-Ferrand June 2020 Not Applicable
NCT04340427 Recruiting Drug: TQB3455 Advanced Malignancies Chia Tai Tianqing Pharmaceutical Group Co. Ltd. April 10 2020 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Histone Demethylase Signaling Pathway Map

Tags: buy L-2-Hydroxyglutaric acid disodium | L-2-Hydroxyglutaric acid disodium supplier | purchase L-2-Hydroxyglutaric acid disodium | L-2-Hydroxyglutaric acid disodium cost | L-2-Hydroxyglutaric acid disodium manufacturer | order L-2-Hydroxyglutaric acid disodium | L-2-Hydroxyglutaric acid disodium distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID