CAS No. 63512-50-5

Batch: Purity:99.88
Check CoA
L-2-Hydroxyglutaric acid disodium Chemical Structure
Chemical Structure
Check the L-2-Hydroxyglutaric acid disodium product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name disodium;(2S)-2-hydroxypentanedioate
CAS Number 63512-50-5
Molecular Formula
C5H6Na2O5
Molecular Weight (MW) 192.08
SMILES [Na+].[Na+].OC(CCC([O-])=O)C([O-])=O
InChIKey DZHFTEDSQFPDPP-QTNFYWBSSA-L

Ordering Information

Biological Activity

L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite that inhibits histone demethylases and mitochondrial creatine kinase. By targeting 2-oxoglutarate-dependent dioxygenases, including histone lysine demethylases, it promotes global histone methylation. This accumulation alters the chromatin landscape and gene expression, resulting in impaired cell differentiation and contributing to renal oncogenesis and metabolic dysregulation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 38 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.