CAS No. 1253452-78-6
Batch:
Purity:99.41
Chemical Structure
Check the
KS176
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[4-(2-hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]benzamide | |
|---|---|---|
| CAS Number | 1253452-78-6 | |
| Molecular Formula |
C22H19N3O5 |
|
| Molecular Weight (MW) | 405.40 | |
| SMILES | C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)CCO)NC(=O)C3=CC=C(C=C3)[N+](=O)[O-] | |
| InChIKey | LTWQQWSXYYXVGA-UHFFFAOYSA-N |
KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter. By blocking ABCG2-mediated efflux, KS176 inhibits active drug transport across cell membranes, restoring intracellular accumulation of substrate chemotherapeutics. This inhibition reverses multidrug resistance phenotypes in ABCG2-overexpressing cancer cells, enhancing sensitivity to targeted therapies and chemotherapeutic agents in preclinical models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 3 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.