JQ-EZ-05 (JQEZ5)

Catalog No.S8607

JQ-EZ-05 (JQEZ5) Chemical Structure

Molecular Weight(MW): 542.68

JQ-EZ-05 is a specific and reversible EZH1/2 inhibitor.

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Choose Selective Histone Methyltransferase Inhibitors

Biological Activity

Description JQ-EZ-05 is a specific and reversible EZH1/2 inhibitor.
Targets
EZH1 [1]
()
EZH2 [1]
()
Assay
Methods Test Index PMID
Western blot
H3K27me1 / H3K27me2 / H3K27me3 / H3K79me2 / H3K27ac ; 

PubMed: 27312177     


(A) H661 and H292 human lung cancer cells were incubated with increasing concentrations of JQEZ5. Cell lysates were prepared and subjected to SDS-PAGE and analysis by Western blotting with the indicated antibodies. (B) Western blots of methylation levels in human lung cancer cell line H661, 72h after treatment with increasing concentrations of JQEZ23. H3 is a loading control. (C) Western blots of methylation levels in H661 human lung cancer cell line after 48 h or 72 h of treatment with increasing concentrations of JQEZ5. H3 is a loading control.

27312177
Growth inhibition assay
Cell viability; 

PubMed: 29202477     


Neuroblastoma cells treated with the EZH2 inhibitor JQEZ5 for 5 days in vitro. Results are representative of 3 independent experiments; data represent mean ± SD of 4 technical replicates. 

29202477

Protocol

Solubility (25°C)

Chemical Information

Molecular Weight 542.68
Formula

C30H38N8O2

CAS No. 1913252-04-6
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Histone Methyltransferase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID