CAS No. 1913252-04-6

Batch: Purity:99.48
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JQ-EZ-05 (JQEZ5) Chemical Structure
Chemical Structure
Check the JQ-EZ-05 (JQEZ5) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)-3-pyridinyl]-1-propan-2-ylpyrazolo[5,4-b]pyridine-4-carboxamide
CAS Number 1913252-04-6
Molecular Formula

C30H38N8O2
Molecular Weight (MW) 542.68
SMILES CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=CC(=NC3=C2C=NN3C(C)C)C4=CN=C(C=C4)N5CCN(CC5)C
InChIKey LQTWDAYNGMMHLV-UHFFFAOYSA-N

Ordering Information

Biological Activity

JQ-EZ-05 (JQEZ5) is a specific and reversible inhibitor of enhancer of zeste homolog 1 and 2 (EZH1/2). By targeting the catalytic subunits of Polycomb Repressive Complex 2 (PRC2), JQ-EZ-05 blocks the trimethylation of histone H3 at lysine 27 (H3K27me3). This target inhibition leads to derepression of PRC2-silenced genes, suppression of epigenetic transcriptional repression, and inhibition of cellular proliferation in responsive cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 6 mg/mL (11.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 6 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.