JH-X-119-01

Catalog No.S9780

For research use only.

JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK1 with IC50 of 9 nM.

JH-X-119-01 Chemical Structure

CAS No. 2227368-54-7

Purity & Quality Control

Choose Selective IRAK Inhibitors

Biological Activity

Description JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK1 with IC50 of 9 nM.
Targets
IRAK1 [1]
(Cell-free assay)
9 nM
In vitro

JH-X-119-01 is a highly efficient and selective covalent inhibitor of interleukin 1 (IL-1) receptor-associated kinase (IRAK) 1 and irreversibly labels IRAK1 at C302, showing moderate cell killing effects with EC50s ranging from 0.59 to 9.72 μM in a panel of WM cells, DLBCL cells, and lymphoma cells.<sup><a class="sref" href="#s_ref">[1]</a></sup>

Protocol (from reference)

Cell Research:

<sup><a class="sref" href="#s_ref">[1]</a></sup>

  • Cell lines: WM cells, DLBCL cells, and lymphoma cells
  • Concentrations: --
  • Incubation Time: 72 h
  • Method:

    CellTiter-Glo assay

Chemical Information

Molecular Weight 452.46
Formula

C25H20N6O3

CAS No. 2227368-54-7
Storage 3 years -20°C powder
2 years -80°C in solvent

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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