CAS No. 2227368-54-7
Batch:
Purity:98.8
Chemical Structure
Check the
JH-X-119-01
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[4-[[3-(prop-2-enoylamino)benzoyl]amino]phenyl]-6-(1H-pyrazol-5-yl)pyridine-2-carboxamide | |
|---|---|---|
| CAS Number | 2227368-54-7 | |
| Molecular Formula |
C25H20N6O3 |
|
| Molecular Weight (MW) | 452.46 | |
| SMILES | C=CC(=O)NC1=CC=CC(=C1)C(=O)NC2=CC=C(NC(=O)C3=NC(=CC=C3)C4=CC=N[NH]4)C=C2 | |
| InChIKey | WQVPGYMGERDXLH-UHFFFAOYSA-N |
JH-X-119-01 functions as a highly potent and selective covalent inhibitor of interleukin-1 receptor-associated kinase 1 (IRAK1). Target-specific inhibition of IRAK1 disrupts key signaling cascades, leading to the cellular suppression of downstream NF-kB and MAPK pathway activation. Consequently, this targeted inhibition reduces pro-inflammatory cytokine production, downregulates cellular inflammatory signaling, and attenuates aberrant immune responses in various cell-based experimental models. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
90 mg/mL
(198.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.