GS-621763

Catalog No.E1112

For research use only.

GS-621763, an orally bioavailable prodrug of GS-441524, shows a dose-dependent antiviral effect on SARS-CoV-2 reporter virus expressing nanoluciferase (SARS-CoV-2 nLUC) replication with an EC50 of 2.8 μM, also inhibits reporter SARS-CoV-2 expressing firefly luciferase (SARS-CoV-2 Fluc) replication with EC50 of 0.125 μM. 

GS-621763 Chemical Structure

CAS No. 2647442-13-3

Purity & Quality Control

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Biological Activity

Description GS-621763, an orally bioavailable prodrug of GS-441524, shows a dose-dependent antiviral effect on SARS-CoV-2 reporter virus expressing nanoluciferase (SARS-CoV-2 nLUC) replication with an EC50 of 2.8 μM, also inhibits reporter SARS-CoV-2 expressing firefly luciferase (SARS-CoV-2 Fluc) replication with EC50 of 0.125 μM. 
Targets
SARS-CoV-2 [1]
(in vitro assays for antiviral activity)
SARS-CoV-2 [1]
(in vitro assays for antiviral activity)
0.125 μM(EC50) 2.8 μM(EC50)

Protocol (from reference)

Chemical Information

Molecular Weight 501.53
Formula

C24H31N5O7

CAS No. 2647442-13-3
Storage 3 years -20°C powder
2 years -80°C in solvent

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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