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Technical Data
| Formula | C6H12F2N2O2.HCl.H2O |
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| Molecular Weight | 236.64 | CAS No. | 96020-91-6 | |
| Solubility (25°C)* | In vitro | Water | 47 mg/mL (198.61 mM) | |
| DMSO | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Eflornithine (DFMO) hydrochloride hydrate inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours. | |
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| In vitro | When cultured cells are treated with α-difluoromethyl-Orn, an inhibitor of polyamine biosynthesis, production of hydrogen peroxide is suppressed and programmed cell death did not occur[1]. |
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| In vivo | Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension |
Protocol (from reference)
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References
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Selleck's Eflornithine (DFMO) hydrochloride hydrate has been cited by 8 publications
| WR1065 conjugated to thiol-PEG polymers as novel anticancer prodrugs: broad spectrum efficacy, synergism, and drug resistance reversal [ Front Oncol, 2023, 13:1212604] | PubMed: 37576902 |
| Postinfection Metabolic Reprogramming of the Murine Trigeminal Ganglion Limits Herpes Simplex Virus-1 Replication [ mBio, 2022, 13(5):e0219422] | PubMed: 36043789 |
| The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia [ iScience, 2022, 25(3):103881] | PubMed: 35243242 |
| Arginine Regulates Zygotic Genome Activation in Porcine Embryos Under Nutrition Restriction [ Front Vet Sci, 2022, 9:921406] | PubMed: 35812864 |
| Metabolic modeling of single Th17 cells reveals regulators of autoimmunity [ Cell, 2021, S0092-8674(21)00700-5] | PubMed: 34216539 |
| Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer [ Int J Mol Sci, 2021, 22(19)10255] | PubMed: 34638596 |
| Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer [ Int J Mol Sci, 2021, 22(19), 10255] | PubMed: None |
| Difluoromethylornithine, a Decarboxylase 1 Inhibitor, Suppresses Hepatitis B Virus Replication by Reducing HBc Protein Levels. [ Front Cell Infect Microbiol, 2020, 16;10:158] | PubMed: 32373551 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.