CAS No. 5355-16-8
Batch:
Purity:99.82
Chemical Structure
Check the
Diaveridine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[(3,4-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine | |
|---|---|---|
| CAS Number | 5355-16-8 | |
| Molecular Formula |
C13H16N4O2 |
|
| Molecular Weight (MW) | 260.29 | |
| SMILES | COC1=C(C=C(C=C1)CC2=CN=C(N=C2N)N)OC | |
| InChIKey | LDBTVAXGKYIFHO-UHFFFAOYSA-N |
Diaveridine is a synthetic pyrimidine derivative and dihydrofolate reductase inhibitor with antiparasitic and coccidiostatic activities. It targets microbial dihydrofolate reductase to block the reduction of dihydrofolate to tetrahydrofolate, thereby disrupting essential folic acid synthesis and folate metabolism pathways. Consequently, inhibition of this pathway impairs nucleotide biosynthesis, suppresses nucleic acid production, and inhibits cellular proliferation in susceptible parasites including coccidia and species of Pneumocystis.[1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
25 mg/mL
(96.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.