Home Microbiology Parasite inhibitor DDD107498

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DDD107498 Parasite inhibitor

Cat.No.S0081

DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. This compound exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.
DDD107498 Parasite inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 462.56

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Quality Control

Batch: S008101 DMSO]93 mg/mL]false]Water]93 mg/mL]false]Ethanol]Insoluble]false Purity: 98.77%
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98.77

Solubility

In vitro
Batch:

DMSO : 93 mg/mL (201.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 93 mg/mL

Ethanol : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 462.56 Formula

C27H31FN4O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1469439-69-7 -- Storage of Stock Solutions

Synonyms M-5717, DDD-498 Smiles C1CCN(C1)CCNC(=O)C2=CC(=NC3=C2C=C(C=C3)F)C4=CC=C(C=C4)CN5CCOCC5

Mechanism of Action

In vitro

This compound shows excellent activity against 3D7 parasites, with no toxic to human cells (MRC5 and Hep-G2 cells) at much higher concentrations.
In vivo

There is a lag of about 24-48 h, during which time the effects of DDD107498 are reversible following wash-out. Rapid killing occurred after parasites when exposed to this compound for more than 48 h.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03261401 Completed
Healthy
Merck KGaA Darmstadt Germany
 September 15 2017 Phase 1

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