Ceapin-A7

Catalog No.E1099 Batch:E109901

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Technical Data

Formula

C20H12F6N4O3
Molecular Weight 470.32 CAS No. 2323027-38-7
Solubility (25°C)* In vitro DMSO 100 mg/mL (212.62 mM)
Ethanol 8 mg/mL (17.0 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO Corn oil
1.65mg/ml Taking the 1 mL working solution as an example, add 50 μL of 33 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description

Ceapin-A7 is a selective and highly potent inhibitor of the ATF6α, which can activate the response to ER stress, with IC50 of 0.59 μM.
Targets
ATF6α [1]
0.59 μM
In vitro

Ceapin-A7 inhibits activation of ATF6α in response to ER stress without inhibiting ATF6β or SREBP activation. In U2-OS cells, Ceapin-A7 inhibits ER stress-induced upregulation of BiP.[1]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    U2-OS cells

  • Concentrations

    6 μM

  • Incubation Time

    8 h

  • Method

    U2-OS cells are treated without or with ER stressor in the absence or presence of 6 μM Ceapin-A7. After eight hours, cells are harvested and analyzed by Western Blot for BiP and GAPDH.

Selleck's Ceapin-A7 has been cited by 3 publications

A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma [ Cell Discov, 2023, 9(1):7] PubMed: 36650126
Knockdown of NR3C1 inhibits the proliferation and migration of clear cell renal cell carcinoma through activating endoplasmic reticulum stress-mitophagy [ J Transl Med, 2023, 21(1):701] PubMed: 37807060
Knockdown of NR3C1 inhibits the proliferation and migration of clear cell renal cell carcinoma through activating endoplasmic reticulum stress-mitophagy [ J Transl Med, 2023, 21(1):701] PubMed: 37807060

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.