Home Metabolism Epoxide Hydrolase

Epoxide Hydrolase

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S4991 Valpromide Valpromide (Depamide, Dipropylacetamide, 2-propylpentanamide) is an antiepileptic drug, derivative of Valproic acid (VPA), used as a mood-stabilizer in bipolar disorder. This compound inhibits both viral and cellular gene expression. It is a human epoxide hydrolase inhibitor.
J Korean Med Sci, 2025, 40(33):e199
Biochem Biophys Res Commun, 2022, 606:94-99
Oncol Lett, 2020, 19(1):460-468
E0473 CUDA CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively, also selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity.
S0752 AUDA AUDA (compound 43) is a potent inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 18 nM and 69 nM for the mouse sEH and human sEH, respectively. This compound has anti-inflammatory activity that reduces the protein expression of MMP-9, IL-1β, TNF-α and TGF-β. It downregulates Smad3 and p38 signaling pathways.
S0548 1-Cyclohexyl-3-dodecyl urea 1-Cyclohexyl-3-dodecyl urea (CDU, N-Cyclohexyl-N-dodecyl urea, NCND) is a highly selective inhibitor of soluble epoxide hydrolase (sEH) that increases epoxyeicosatrienoic acids (EETs) levels.
E2847 TPPU TPPU is a soluble epoxide hydrolase (sEH) inhibitor with IC50 values of 37 and 3.7 nM for monkey and human sEH, respectively.