Home Apoptosis Ferroptosis inhibitor Bufotalin

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Bufotalin Ferroptosis inhibitor

Cat.No.S0910

Bufotalin is a bufadienolide from Venenum bufonis that acts as a novel inhibitor of GPX4 and induces iron-dependent ferroptosis in non-small cell lung cancer (NSCLC) cells, significantly reducing proliferation by accelerating GPX4 degradation and increasing intracellular Fe2+.
Bufotalin Ferroptosis inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 444.56

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Quality Control

Batch: S091002 DMSO]89 mg/mL]false]Ethanol]89 mg/mL]false]Water]Insoluble]false Purity: 99.59%
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99.59

Solubility

In vitro
Batch:

DMSO : 89 mg/mL (200.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 89 mg/mL

Water : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 444.56 Formula

C26H36O6

 Storage (From the date of receipt)
CAS No. 471-95-4 Download SDF Storage of Stock Solutions

Mechanism of Action

In vivo

Bufotalin (0.5-1 mg/kg; intraperitoneal injection; twice daily; for 7 days) treatment shows a significantly reduced tumor growth in mice.
References

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