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AXKO-0046 hydrochloride LDH inhibitor

Name: AXKO-0046 hydrochloride
Brand: Selleck Chemicals
SKU: E4635
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E4635

AXKO-0046 hydrochloride is an indole-derived, selective LDHB inhibitor that acts through an uncompetitive mechanism, with an EC50 of 42 nM. It binds an allosteric site distinct from the catalytic active site and shows selectivity over LDHA.

AXKO-0046 hydrochloride LDH inhibitor Chemical Structure

Molecular Weight: 375.55

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Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism
Other LDH Inhibitors	Sodium oxamate AZ-33 FX-11 (LDHA Inhibitor FX11) Galloflavin LDHA-IN-3 Pyruvic acid Chinese Gallnut Extract Oxamic acid Isomalt

Solubility

In vitro
Batch:

DMSO : 90 mg/mL (239.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 5 mg/mL

Water : 4 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	375.55	Formula	C₂₅H₃₃N₃	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.		Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/34725423/

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Handling Instructions

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