CAS No. 508186-14-9
| IUPAC Name | 1-(2,3-dithiophen-2-ylquinoxalin-6-yl)-3-(2-methoxyethyl)urea | |
|---|---|---|
| CAS Number | 508186-14-9 | |
| Molecular Formula |
C20H18N4O2S2 |
|
| Molecular Weight (MW) | 410.51 | |
| SMILES | COCCNC(=O)NC1=CC2=C(C=C1)N=C(C(=N2)C3=CC=CS3)C4=CC=CS4 | |
| InChIKey | CTPVNWVUAGMHEJ-UHFFFAOYSA-N |
Ac-CoA Synthase Inhibitor1 is a potent and selective inhibitor of acyl-CoA synthetase short-chain family member 2 (ACSS2), which converts acetate into acetyl-CoA. By targeting ACSS2, this compound disrupts downstream lipid biosynthesis, histone acetylation, and nutrient stress adaptation in cancer cells. Furthermore, inhibition of ACSS2 blocks acetate-dependent metabolic pathways and suppresses viral replication, including respiratory syncytial virus (RSV) infection in cellular models. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
15 mg/mL
(36.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| DMSO |
220 mg/mL
(535.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) Solubility in DMSO
- Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) Stock Solution
- Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) Storage
- Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) Stability
- Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) Molecular Weight
- Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) SMILES
- Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) Chemical Structure (2D and 3D)
- Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) SDS｜MSDS