Catalog No.S1725 Synonyms: SF 86-327

For research use only.

Terbinafine (SF 86-327) is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.

Terbinafine  Chemical Structure

CAS No. 91161-71-6

Selleck's Terbinafine has been cited by 4 Publications

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Biological Activity

Description Terbinafine (SF 86-327) is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.
squalene epoxidase [1]
In vitro

Terbinafine (50 μM to 100 μM) inhibits only marginally the metabolism of ethoxycoumarin (CYP1A2), tolbutamide (CYP2C9), or ethynylestradiol, CsA, and cortisol. Terbinafine proves to be a potent inhibitor of the CYP2D6-mediated dextromethorphan O-demethylation and bufuralol 1-hydroxylation with IC50values of 0.2 μM and 0.25 μM, respectively. [1] Terbinafine is highly activ Aspergillus isolates (minimum inhibitory concentration [MIC] 0.01 to 2 mg/mL) with a primary fungicidal action (minimum fungicidal concentration [MFC] 0.02 to 4 mg/mL). [2] Terbinafine inhibits dextromethorphan O-demethylation with an apparent Ki ranging from 28 to 44 nM in human hepatic microsomes and averaging 22.4 nM for the heterologously expressed enzymes. [3] Terbinafine shows a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. [4] Terbinafine decreases the levels of phosphorylated extracellular signal-regulated kinase (ERK). Terbinafine might cause a decrease of MEK, which in turn up-regulates p53 through the inhibition of ERK phosphorylation, and finally causes an increase of p21expression and cell-cycle arrest. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 291.43


CAS No. 91161-71-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)(C)C#CC=CCN(C)CC1=CC=CC2=CC=CC=C21

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04880980 Completed Drug: Terbinafine Pill|Drug: Itraconazole capsule Dermatophyte Infection|Terbinafine Adverse Reaction|Itraconazole Adverse Reaction Pak Emirates Military Hospital March 15 2021 Phase 3
NCT04188574 Active not recruiting Drug: BB2603-1|Drug: BB2603-3|Drug: BB2603-10|Other: Vehicle Distal Subungual Onychomycosis|Fungal Infection|Fungus Nail Blueberry Therapeutics|IQVIA Biotech March 22 2021 Phase 2
NCT01484145 Completed Drug: Terbinafine HCl Onychomycosis Nitric BioTherapeutics Inc December 2011 Phase 2
NCT01772212 Completed Drug: Terbinafine 250 mg Mycoses GlaxoSmithKline February 24 2011 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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