Name: Hydrochlorothiazide
Brand: Selleck Chemicals
SKU: S1708
Availability: InStock
Rating: 5 (4 reviews)

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Quality Control

Batch: S170801 0.5MNAOH]3 mg/mL]false]DMSO]0 mg/mL]false]Water]0 mg/mL]false Purity: 99.86%

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COA
NMR
SDS/MSDS
Datasheet

99.86

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Solubility

In vitro
Batch:

0.5MNAOH : 3 mg/mL

DMSO : 0 mg/mL (0.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 0 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Clear solution	5%0.5MNAOH 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.15mg/ml (0.50mM)	Taking the 1 mL working solution as an example, add 50 μL of 3 mg/ml clarified 0.5MNAOH stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% 0.5MNAOH 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.021mg/ml (0.07mM)	Taking the 1 mL working solution as an example, add 50 μL of 0.42 mg/ml clear 0.5MNAOH stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	297.74	Formula	C₇H₈ClN₃O₄S₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	58-93-5	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			SMILES	C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-06-13)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07020104	RECRUITING	Chronic Kidney Diseases	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	2025-01-07
NCT00162474	RECRUITING	Healthy	Hadassah Medical Organization	2003-09
NCT05373264	RECRUITING	ADPKD	University Medical Center Groningen	2024-07-31	PHASE3
NCT07458880	RECRUITING	Intracerebral Hemorrhage	The University of Hong Kong	2026-03-01
NCT07687160	NOT_YET_RECRUITING	Hypertension	Ottawa Hospital Research Institute	2026-09-01	PHASE4
NCT07469722	NOT_YET_RECRUITING	Acute Heart Failure (AHF); Congestive Heart Failure Acute; Diuretic Effect; Lung Ultrasonography Score; Ultrasonography, Doppler; Point-of-care Ultrasound (POCUS)	Hospital de Clinicas de Porto Alegre	2026-03-23	PHASE2; PHASE3

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Hydrochlorothiazide

Chemical Structure

Molecular Weight: 297.74