CAS No. 58-93-5
Batch:
Purity:99.86
Chemical Structure
Check the
Hydrochlorothiazide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide | |
|---|---|---|
| CAS Number | 58-93-5 | |
| Molecular Formula |
C7H8ClN3O4S2 |
|
| Molecular Weight (MW) | 297.74 | |
| SMILES | C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl | |
| InChIKey | JZUFKLXOESDKRF-UHFFFAOYSA-N |
Hydrochlorothiazide is a thiazide class diuretic compound that acts as an inhibitor of the renal sodium-chloride cotransporter (NCC/SLC12A3). Inhibition of this cotransporter impairs sodium and chloride reabsorption in the distal convoluted tubule of the nephron. This blockade enhances renal excretion of sodium, chloride, and water, thereby modulating systemic electrolyte balance and renal fluid transport pathways. [1][2]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| 0.5MNAOH | 3 mg/mL |
| DMSO |
0 mg/mL
(0.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | 0 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Hydrochlorothiazide Clinical Trials
- Hydrochlorothiazide Solubility in DMSO
- Hydrochlorothiazide Stock Solution
- Hydrochlorothiazide Storage
- Hydrochlorothiazide Stability
- Hydrochlorothiazide Molecular Weight
- Hydrochlorothiazide SMILES
- Hydrochlorothiazide Chemical Structure (2D and 3D)
- Hydrochlorothiazide SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.