Hydrochlorothiazide Clinical Trials

Size	Price	Qty
50mg	USD 147
1g	USD 670

Clinical Trials

Hydrochlorothiazide has been evaluated in numerous clinical trials across early phase through Phase 4 studies to examine its efficacy, pharmacokinetics, and renal oxygenation. Sponsored by pharmaceutical corporations and academic medical centers, these evaluations encompass recruitment statuses ranging from actively recruiting to completed, suspended, terminated, or withdrawn. The trials involve healthy volunteers as well as patient populations with conditions including primary and essential arterial hypertension, type 2 diabetes mellitus, metabolic syndrome, chronic kidney insufficiency, and hemodialysis management.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07020104	RECRUITING	Chronic Kidney Diseases	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	2025-01-07
NCT00162474	RECRUITING	Healthy	Hadassah Medical Organization	2003-09
NCT05373264	RECRUITING	ADPKD	University Medical Center Groningen	2024-07-31	PHASE3
NCT07458880	RECRUITING	Intracerebral Hemorrhage	The University of Hong Kong	2026-03-01
NCT07687160	NOT_YET_RECRUITING	Hypertension	Ottawa Hospital Research Institute	2026-09-01	PHASE4
NCT07469722	NOT_YET_RECRUITING	Acute Heart Failure (AHF); Congestive Heart Failure Acute; Diuretic Effect; Lung Ultrasonography Score; Ultrasonography, Doppler; Point-of-care Ultrasound (POCUS)	Hospital de Clinicas de Porto Alegre	2026-03-23	PHASE2; PHASE3
NCT06111885	RECRUITING	Kidney Stone	Insel Gruppe AG, University Hospital Bern	2024-10-01	PHASE2
NCT07634068	NOT_YET_RECRUITING	Vertebrobasilar Dolichoectasia	Huashan Hospital	2026-06	PHASE2
NCT07593612	NOT_YET_RECRUITING	Acute Heart Failure (AHF)	Lucrecia Maria Burgos	2026-06-15	PHASE4
NCT07271420	RECRUITING	Hypertension; Peritoneal Dialysis; End Stage Kidney Disease (ESRD)	Chinese University of Hong Kong	2020-01-01	PHASE4
NCT04676399	ACTIVE_NOT_RECRUITING	Chronic Pain; Hypertension; Diuretics Drug Reactions; SCS	University of Kansas Medical Center	2022-02-08	EARLY_PHASE1
NCT04934228	RECRUITING	Blood Pressure; Diabetes; Obesity; Insulin Resistance; Diuretics Drug Reactions; Sympathetic Nerve Activity	University of Kansas Medical Center	2021-07-01	PHASE1
NCT07683585	RECRUITING	Hypertension; Coronary Arterial Disease; Percutaneous Coronary Intervention	National Medical Research Center for Therapy and Preventive Medicine	2026-04-01
NCT07544888	COMPLETED	Heart Diseases; Hypertension	Shaikh Zayed Hospital, Lahore	2025-11-01	PHASE1
NCT06041529	ACTIVE_NOT_RECRUITING	Essential Hypertension	Yuhan Corporation	2023-10-18	PHASE4
NCT05171686	COMPLETED	Chronic Kidney Disease; Hypertension	VA Office of Research and Development	2023-02-01	PHASE4
NCT05917275	UNKNOWN	Primary Hypertension	Radboud University Medical Center	2024-04-04	PHASE4
NCT04423627	COMPLETED	Hypertension, Systolic; Stiffness, Aortic	University of Iowa	2021-06-01	EARLY_PHASE1
NCT06491940	UNKNOWN	Proteinuria	RESnTEC, Institute of Research	2024-08-01
NCT02483936	WITHDRAWN	Arterial Hypertension	EMS		PHASE3
NCT02493322	WITHDRAWN	Essential Arterial Hypertension	EMS		PHASE3
NCT03298802	TERMINATED	Pre-Eclampsia; Gestational Hypertension; Superimposed Pre-Eclampsia; Hypertension, Pregnancy-Induced; Postpartum Pregnancy-Induced Hypertension; Postpartum Preeclampsia	The University of Texas Medical Branch, Galveston	2017-11-21	PHASE3
NCT05920005	COMPLETED	Hypertension	Hospital Israelita Albert Einstein	2023-08-22	PHASE3
NCT05443932	UNKNOWN	Urolithiasis; Hyperoxaluria	Medical University of Vienna	2024-03-04	PHASE4
NCT06362668	COMPLETED	Acute Decompensated Heart Failure	Reprieve Cardiovascular, Inc	2024-05-17
NCT03946514	COMPLETED	Hypertension	Shanghai Jiao Tong University School of Medicine	2018-09-01	PHASE4
NCT06205407	COMPLETED	Healthy Participants	Pfizer	2023-12-26	PHASE1
NCT04927299	COMPLETED	Essential Arterial Hypertension	Laboratorios Silanes S.A. de C.V.	2022-06-30	PHASE3
NCT03109795	TERMINATED	Anxiety; Hypertension	University of Iowa	2017-04-10	PHASE4
NCT03423355	WITHDRAWN	Type 2 Diabetes Mellitus (T2DM)	University Hospital Tuebingen	2021-09	PHASE4
NCT05685277	COMPLETED	Bioequivalence	Pharmtechnology LLC	2022-12-28	PHASE1
NCT03892148	COMPLETED	Heart Failure; Acute Heart Failure; Chronic Heart Failure	University Hospital, Clermont-Ferrand	2019-05-17	PHASE4
NCT02185417	COMPLETED	Hypertension	VA Office of Research and Development	2016-06-15	PHASE3
NCT03179163	TERMINATED	Hypertension,Essential	Penn State University	2016-07-20	PHASE1; PHASE2
NCT04465123	UNKNOWN	Acute Heart Failure; Acute Kidney Injury	Chiang Mai University	2020-08-13	PHASE3
NCT05049616	COMPLETED	Hypertension in Pregnancy; Postpartum Preeclampsia	The University of Texas Health Science Center, Houston	2021-10-18	PHASE4
NCT04964050	WITHDRAWN	Healthy Volunteers	GlaxoSmithKline	2022-04-21	PHASE1
NCT04964050	Withdrawn	Healthy Volunteers	GlaxoSmithKline	2022-04-21	Phase 1
NCT03057431	COMPLETED	Nephrolithiasis	Insel Gruppe AG, University Hospital Bern	2017-03-09	PHASE3
NCT04654312	COMPLETED	Photosensitivity	Universität des Saarlandes	2021-01-18	PHASE1
NCT05040880	Completed	Hypertension	HK inno.N Corporation	2021-07-08	Phase 1
NCT03928145	UNKNOWN	Hypertension	Hospital de Clinicas de Porto Alegre	2019-11-13	PHASE3
NCT04103411	UNKNOWN	Hypertension,Essential; Exercise Activity	Anil Nigam	2018-04-26
NCT03461003	COMPLETED	Pediatric Hypertension	The University of Texas Health Science Center, Houston	2018-04-02	PHASE4
NCT03971929	COMPLETED	Hypertension	Jiangsu HengRui Medicine Co., Ltd.	2019-07-31	PHASE1
NCT06681116	COMPLETED	Renal Stones; Idiopathic Hypercalciuria	ALI KAMAL M. SAMI	2015-02-16
NCT03170336	COMPLETED	Chronic Kidney Diseases	Guangdong Provincial People's Hospital	2018-03-01	PHASE4
NCT03147092	UNKNOWN	Hypertension; Blood Pressure	Centro Neurológico de Pesquisa e Reabiitação, Brazil	2018-02-01	EARLY_PHASE1
NCT01983462	TERMINATED	Obesity; Prehypertension; Hypertension	Gary L. Pierce	2013-10	PHASE2
NCT03640221	WITHDRAWN	Hypertension; Diabetes Mellitus, Type 2	Cedars-Sinai Medical Center	2018-09-01	PHASE4
NCT03978884	WITHDRAWN	Diabetes Mellitus; Hypertension	The University of The West Indies	2019-06-01	PHASE4
NCT02824718	COMPLETED	Autosomal Dominant Hypocalcemia OR Primary Hypoparathyroidism Related to Other Cause But Complicated by Hypercalciuria Under Treatment	Assistance Publique - Hôpitaux de Paris	2017-06-06	PHASE2
NCT03254849	COMPLETED	Type 2 Diabetes Mellitus	Profil Institut für Stoffwechselforschung GmbH	2017-12-08	PHASE4
NCT04182854	UNKNOWN	Diuretic Abuse	Capital Medical University	2019-10-28
NCT04521023	COMPLETED	Hypertension	Chong Kun Dang Pharmaceutical	2017-09-20	PHASE4
NCT04242758	UNKNOWN	Renal Function Disorder; Glucose Metabolism Disorders	University of Pisa	2019-06-04	PHASE4
NCT04138888	UNKNOWN	Bioequivalence	Pharmtechnology LLC	2019-10-31	PHASE1
NCT01647932	COMPLETED	Heart Failure	Spanish Society of Internal Medicine	2014-10	PHASE3
NCT03658850	UNKNOWN	Hypernatremia; Critical Illness	University of Sao Paulo	2018-10-01	PHASE2
NCT02046395	COMPLETED	Type 2 Diabetes; Hypertension	Tulane University School of Medicine	2012-01	PHASE4
NCT06083116	COMPLETED	Diabetes in Adults	Jiangsu HengRui Medicine Co., Ltd.	2019-08-28	PHASE1
NCT03578042	UNKNOWN	Hypertension	Hotel Dieu de France Hospital	2017-04-01	PHASE4
NCT03246555	COMPLETED	The Elderly (≥ 70 Years) With Essential Hypertension	Boryung Pharmaceutical Co., Ltd	2016-07-15	PHASE3
NCT06083116	Completed	Diabetes in Adults	Jiangsu HengRui Medicine Co. Ltd.	2019-08-28	Phase 1
NCT04952051	COMPLETED	Hypertension	Second Affiliated Hospital, Zhejiang University, School of Medicine	2014-07-01	PHASE3
NCT03951558	UNKNOWN	Hypercalciuria; Idiopathic; Nephrolithiasis	Hospital Infantil de Mexico Federico Gomez	2018-05-11
NCT04197622	COMPLETED	Healthy Volunteers	Parc de Salut Mar	2019-03-05	PHASE1
NCT04197622	Completed	Healthy Volunteers	Parc de Salut Mar	2019-03-05	Phase 1
NCT02278471	COMPLETED	Hypertension; Hyperlipidemia	Vanderbilt University	2015-12	PHASE2
NCT02742467	COMPLETED	Hypertension	University of Abuja	2017-06-07	PHASE4
NCT01922141	WITHDRAWN	Hypertension	Novartis Pharmaceuticals	2015-05	PHASE4
NCT03082742	UNKNOWN	Secondary Hyperparathyroidism; Chronic Kidney Disease	University of Sao Paulo General Hospital	2015-08-01
NCT02875886	COMPLETED	Chronic Kidney Disease	Erasmus Medical Center	2016-09	PHASE4
NCT03387657	COMPLETED	Type 2 Diabetes Mellitus	Sanofi	2018-01-03	PHASE1
NCT03390465	COMPLETED	Drug-Drug Interaction	Boryung Pharmaceutical Co., Ltd	2017-12-15	PHASE1
NCT02646397	UNKNOWN	Chronic Kidney Disease	Shanghai Changzheng Hospital	2016-02	PHASE4
NCT02591160	COMPLETED	Hyperparathyroidism	University of Missouri-Columbia	2015-05
NCT02744456	COMPLETED	Hypertension; High Blood Pressure	Columbia University	2014-08-01	EARLY_PHASE1
NCT02900729	UNKNOWN	Hypertension	Shanghai WiseGain Medical Devices Co., Ltd.	2016-10	PHASE3
NCT04371874	COMPLETED	Hypertension	First Affiliated Hospital Xi'an Jiaotong University	2014-01
NCT02711670	COMPLETED	Kidney Stones	VA New York Harbor Healthcare System	2014-02
NCT01748123	WITHDRAWN	Hypertension	Johns Hopkins University	2016-08	PHASE4
NCT02377661	COMPLETED	Hypertension	Wilhelminenspital Vienna	2015-03	PHASE4
NCT02214498	UNKNOWN	Essential Hypertension	Erasmus Medical Center	2015-05	PHASE4
NCT02521246	WITHDRAWN	Essential Arterial Hypertension	EMS	2016-11	PHASE3
NCT02521233	WITHDRAWN	Essential Arterial Hypertension	EMS	2016-11	PHASE3
NCT03031496	COMPLETED	Hypertension	GlaxoSmithKline	2017-03-17	PHASE1
NCT00223717	COMPLETED	Hypertension	Vanderbilt University	2001-01	PHASE1
NCT03032315	COMPLETED	Healthy	IlDong Pharmaceutical Co Ltd	2016-10-01	PHASE1
NCT01819441	UNKNOWN	Cerebral Small Vessel Diseases	Yining Huang	2012-05	PHASE4
NCT02100462	UNKNOWN	Hypertension	Creighton University	2014-03	PHASE4
NCT02738632	COMPLETED	Essential Hypertension	IlDong Pharmaceutical Co Ltd	2015-05	PHASE3
NCT02412761	COMPLETED	Essential Hypertension	The University of Texas Health Science Center, Houston	2013-06
NCT02699125	COMPLETED	Obstructive Sleep Apnea	University of California, San Diego	2015-01	PHASE4
NCT01996085	COMPLETED	Arterial Hypertension	Military Institute od Medicine National Research Institute	2013-01
NCT02294539	COMPLETED	Hypertension	Chong-Jin Kim	2014-08	PHASE4
NCT02277691	COMPLETED	Essential Hypertension	Takeda	2014-11-07	PHASE3
NCT02739672	COMPLETED	Healthy	IlDong Pharmaceutical Co Ltd	2016-01-02	PHASE1
NCT01879527	UNKNOWN	Optic; Neuritis, With Demyelination	Medical University of Vienna	2014-03	PHASE2
NCT02710071	COMPLETED	Hypertension	University of California, San Diego	2015-01	PHASE4
NCT02373163	COMPLETED	Blood Pressure, High	Prevencion	2014-09-01	PHASE4
NCT02217852	UNKNOWN	Hypertension	West China Hospital	2014-08	PHASE4
NCT01365481	COMPLETED	Hypertension; Chronic Kidney Disease	Novartis Pharmaceuticals	2011-08	PHASE3
NCT02427880	COMPLETED	Nephrotic Syndrome; Edema	Shiraz University of Medical Sciences	2015-04	PHASE4
NCT02222480	COMPLETED	Hypertension	Boryung Pharmaceutical Co., Ltd	2014-10	PHASE2
NCT01692301	COMPLETED	Hypertension	Novartis Pharmaceuticals	2012-12	PHASE2
NCT01977430	UNKNOWN	Chronic Kidney Insufficiency; Hemodialysis Treatment; Diuresis Preserved	Corporacion Parc Tauli	2013-11	PHASE4
NCT02255253	COMPLETED	Hypertension	The George Institute for Global Health, China	2014-10
NCT01822860	WITHDRAWN	Hypertension	Creighton University	2013-03	PHASE4
NCT01911780	COMPLETED	Hypertension	Boehringer Ingelheim	2013-07	PHASE3
NCT00994617	UNKNOWN	Hypertension, Resistant to Conventional Therapy; Essential Hypertension	University of Cambridge	2010-01	PHASE4
NCT01819220	COMPLETED	Hypertension	Yonsei University	2009-04	PHASE4
NCT01519635	COMPLETED	Hypertension	Centre Hospitalier Universitaire Vaudois	2011-10	PHASE4
NCT02183675	COMPLETED	Healthy	Boehringer Ingelheim	2014-07	PHASE1
NCT00574834	TERMINATED	Metabolic Syndrome	University of Maryland, Baltimore	2007-03	EARLY_PHASE1
NCT01838850	COMPLETED	Essential Hypertension	Daiichi Sankyo Korea Co., Ltd., a Daiichi Sankyo Company	2013-04	PHASE3
NCT02129192	COMPLETED	Healthy	Boehringer Ingelheim	2014-05	PHASE1
NCT02121535	COMPLETED	Healthy	Boehringer Ingelheim	2014-04	PHASE1
NCT01658657	COMPLETED	Hypertension; Plasma Renin Activity	University of North Carolina, Chapel Hill	2012-10
NCT01975246	COMPLETED	Hypertension	Boehringer Ingelheim	2013-11	PHASE3
NCT02094924	COMPLETED	Hypertension	GlaxoSmithKline	2014-04-17	PHASE1
NCT01258764	COMPLETED	Hypertension, Grade 1; Hypertension Treatment; N of 1 Study Design; Hypertension	Scripps Translational Science Institute	2010-11
NCT03889145	COMPLETED	Healthy	IlDong Pharmaceutical Co Ltd	2013-12-19	PHASE1
NCT02466490	COMPLETED	Hypertension, Essential	Stendhal Americas, S.A.	2013-04	PHASE3
NCT01480791	WITHDRAWN	Hypertension; Diabetes	Sir Mortimer B. Davis - Jewish General Hospital	2012-01	PHASE2
NCT02072330	COMPLETED	Grade I or II Essential Hypertension	Takeda	2013-03	PHASE2; PHASE3
NCT00865124	COMPLETED	Type 2 Diabetes Mellitus; Vascular Disease	Brigham and Women's Hospital	2008-09
NCT01692717	COMPLETED	Healthy Subjects	Azidus Brasil	2013-02-28	PHASE1
NCT01858610	COMPLETED	Healthy	Damanhour University	2013-03
NCT01176032	COMPLETED	Hypertension; Left Ventricle Hypertrophy	Novartis Pharmaceuticals	2010-06	PHASE4
NCT01858623	COMPLETED	Healthy Normotensive Participants	Damanhour University	2013-02
NCT00822107	COMPLETED	Gitelman Syndrome	Oregon Health and Science University	2009-01
NCT01415505	COMPLETED	Hypertension	Forest Laboratories	2011-08	PHASE3
NCT01767298	COMPLETED	Healthy Normotensive Participants	Damanhour University	2012-10
NCT00994253	WITHDRAWN	Hypertension; Diabetes Type 2	Corewell Health East	2009-08	PHASE4
NCT00896389	COMPLETED	Hypertension	University of Maryland, Baltimore	2009-10	PHASE4
NCT01767259	COMPLETED	Healthy Normotensive Participants	Damanhour University	2012-10
NCT01259297	TERMINATED	Cardiovascular Events	Novartis Pharmaceuticals	2011-01	PHASE3
NCT01101009	COMPLETED	Hypertension	Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company	2010-04	PHASE4
NCT00478335	COMPLETED	Nephrogenic Diabetes Insipidus	University of Colorado, Denver	2007-05
NCT01827878	COMPLETED	Fed	IPCA Laboratories Ltd.	2012-10	PHASE1
NCT01831700	COMPLETED	Fasting	IPCA Laboratories Ltd.	2012-10	PHASE1
NCT01309828	COMPLETED	Safety	Takeda	2011-03	PHASE3
NCT01103245	COMPLETED	Metabolic Diseases; Diabetes Mellitus; Endocrine System Diseases; Glucose Metabolism Disorders	Vanderbilt University Medical Center	2010-03	PHASE1
NCT00509470	COMPLETED	Essential Hypertension	Tokyo University	2007-07	PHASE4
NCT00656331	WITHDRAWN	Hypertension	University of New Mexico	2005-08
NCT01302691	COMPLETED	Hypertension	Merck Sharp & Dohme LLC	2011-01-01	PHASE3
NCT01256411	COMPLETED	Essential Hypertension	Novartis Pharmaceuticals	2010-11	PHASE2
NCT01030458	COMPLETED	Blood Pressure	KU Leuven	2010-09	PHASE4
NCT01172431	COMPLETED	Hypertension; Renal Insufficiency	West China Hospital	2010-09	PHASE4
NCT01138423	COMPLETED	Hypertension; Abdominal Obesity; Metabolic Syndrome	UMC Utrecht	2010-08	PHASE4
NCT01370655	COMPLETED	Hypertension	Merck Sharp & Dohme LLC	2011-06-15	PHASE1
NCT01258673	COMPLETED	Essential Hypertension	Boryung Pharmaceutical Co., Ltd	2010-11	PHASE3
NCT01302899	TERMINATED	Non-diabetic Nephropathy	Novartis Pharmaceuticals	2011-01	PHASE2
NCT00535925	COMPLETED	Diabetic Nephropathy	University of Campania Luigi Vanvitelli	2005-10	PHASE4
NCT00605072	COMPLETED	Cognitive Impairment; Hypertension; Aging	University of Southern California	2008-01	PHASE2
NCT00996281	COMPLETED	Essential Hypertension	Takeda	2009-10	PHASE3
NCT00834600	COMPLETED	Hypertension	The Louis & Rachel Rudin Foundation	2005-12
NCT01056731	COMPLETED	High Blood Pressure	Novartis	2010-02	PHASE4
NCT01180205	UNKNOWN	Hypertension	Johannes Gutenberg University Mainz	2010-08	PHASE4
NCT01294631	COMPLETED	Healthy	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	2011-03	PHASE1
NCT00902304	COMPLETED	Hypertension	Novartis Pharmaceuticals	2009-07	PHASE4
NCT01276288	COMPLETED	Diabetes Mellitus, Type 2	Boehringer Ingelheim	2011-01	PHASE1
NCT01271374	UNKNOWN	Hypertension	InVasc Therapeutics, Inc.	2010-04	PHASE4
NCT02962258	COMPLETED	Healthy Subjects	Torrent Pharmaceuticals Limited	2011-05	PHASE1
NCT02962336	COMPLETED	Healthy Subjects	Torrent Pharmaceuticals Limited	2011-05	PHASE1
NCT00761904	UNKNOWN	Hypertension; Hyperlipidemia	Brigham and Women's Hospital	2010-12
NCT01096667	COMPLETED	Diabetes Mellitus, Type 2; Hypertension	Merck Sharp & Dohme LLC	2010-05-17	PHASE2
NCT01198249	COMPLETED	Essential Hypertension	Yonsei University	2010-09	PHASE1
NCT00923091	COMPLETED	Essential Hypertension	Daiichi Sankyo	2009-06	PHASE3
NCT00246519	COMPLETED	Hypertension	University of Florida	2005-10	PHASE4
NCT00457483	COMPLETED	Primary Hypertension	Radboud University Medical Center	2007-08	PHASE4
NCT00976495	COMPLETED	Type 2 Diabetes Mellitus	AstraZeneca	2009-10	PHASE2
NCT00795847	COMPLETED	Hypertension	Kurume University	2008-11	PHASE4
NCT00670787	COMPLETED	Hypertension	Kyushu University	2008-06	PHASE3
NCT00797862	COMPLETED	Hypertension	Novartis	2008-11	PHASE3
NCT01033071	COMPLETED	Essential Hypertension	Takeda	2010-01	PHASE3
NCT01070030	COMPLETED	Stage II Hypertension	Novartis	2010-01	PHASE4
NCT00902538	COMPLETED	Essential Hypertension	Daiichi Sankyo	2009-04	PHASE3
NCT00980187	COMPLETED	Hypertension; Type 2 Diabetes Mellitus	LaborMed Pharma S.A.	2008-03	PHASE4
NCT00673790	COMPLETED	Hypertension	Forest Laboratories	2008-05-15	PHASE4
NCT00744237	COMPLETED	Hypertension; Type 2 Diabetes Mellitus	Forest Laboratories	2008-08	PHASE4
NCT01375322	COMPLETED	Hypertension; Diabetes Mellitus, Type 2; Albuminuria	TSH Biopharm Corporation Limited	2007-06	PHASE4
NCT00846365	COMPLETED	Essential Hypertension	Takeda	2009-03	PHASE3
NCT00459056	COMPLETED	Abdominal Obesity; Hypertension	St. Paul Heart Clinic	2007-04	PHASE3
NCT00695955	COMPLETED	Hypertension	Takeda	2007-06	PHASE3
NCT01012479	COMPLETED	Hypertension	Takeda	2009-10	PHASE4
NCT00926289	COMPLETED	Hypertension	Boehringer Ingelheim	2009-06	PHASE4
NCT00446563	COMPLETED	Hypertension; Hypertrophy, Left Ventricular	Novartis	2007-03	PHASE3
NCT00942994	COMPLETED	Hypertension	Novartis	2009-06	PHASE4
NCT00999752	COMPLETED	Hypertension	InVasc Therapeutics, Inc.	2009-10
NCT00871871	COMPLETED	Hypertension	Merck Sharp & Dohme LLC	2009-03	PHASE1
NCT00787605	COMPLETED	Hypertension; Diabetes Mellitus	Novartis	2008-11	PHASE4
NCT00500604	COMPLETED	Hypertension	Sanofi	2007-07	PHASE4
NCT00797316	COMPLETED	Hypertension	Novartis	2008-11	PHASE4
NCT00388388	TERMINATED	Pre-hypertension; Pre-diabetes	Sir Mortimer B. Davis - Jewish General Hospital	2007-03	PHASE2
NCT00690521	COMPLETED	Congestive Heart Failure	University of New Mexico	2004-10-26
NCT00887510	COMPLETED	Hypertension	University of Florida	2007-05	PHASE4
NCT00818883	COMPLETED	Essential Hypertension	Takeda	2009-02	PHASE3
NCT00667719	COMPLETED	Essential Hypertension	Novartis	2008-06-05	PHASE3
NCT00496834	COMPLETED	Hypertension	Organon and Co	2008-02-01	PHASE4
NCT00791258	COMPLETED	Hypertension	Daiichi Sankyo	2008-11	PHASE4
NCT00661895	COMPLETED	Hypertension	Creighton University	2005-08	PHASE4
NCT00765947	COMPLETED	Essential Hypertension ( Mild to Moderate)	Novartis	2008-09	PHASE4
NCT00867490	COMPLETED	Hypertension	Novartis	2009-03	PHASE3
NCT00745953	WITHDRAWN	Metabolic Syndrome; Lipotoxicity	University of Texas Southwestern Medical Center	2007-08	PHASE4
NCT00765674	COMPLETED	Hypertension	Novartis	2008-09	PHASE3
NCT00224549	COMPLETED	Hypertension	Assistance Publique - Hôpitaux de Paris	2005-04	PHASE4
NCT00739674	COMPLETED	Hypertension	Organon and Co	2008-02-01	PHASE3
NCT00708344	COMPLETED	Hypertension	Sanofi	2008-06	PHASE4
NCT01431508	COMPLETED	Hypertension	Organon and Co	2007-08-01	PHASE4
NCT00617877	COMPLETED	Hypertension	Merck Sharp & Dohme LLC	2005-03
NCT00698646	COMPLETED	Hypertension	Novartis Pharmaceuticals	2008-04	PHASE4
NCT00492128	COMPLETED	Hypertension	Yokohama City University Medical Center	2007-09	PHASE4
NCT00923533	COMPLETED	Essential Hypertension	Boryung Pharmaceutical Co., Ltd	2009-03	PHASE1
NCT00546754	COMPLETED	Hypertension	Organon and Co	2007-05-01	PHASE3
NCT00649389	COMPLETED	Hypertension	Daiichi Sankyo	2008-05	PHASE3
NCT00654745	COMPLETED	Type 2 Diabetes; Hypertension	Daiichi Sankyo	2008-05	PHASE4
NCT00760266	COMPLETED	Hypertension	Novartis	2008-09	PHASE4
NCT00705575	COMPLETED	Hypertension	Novartis	2008-06	PHASE3
NCT00670566	COMPLETED	Hypertension	Sanofi	2008-04	PHASE4
NCT00739596	COMPLETED	Hypertension	Novartis Pharmaceuticals	2008-07	PHASE4
NCT00621153	COMPLETED	Stage II Hypertension	AstraZeneca	2008-02	PHASE4
NCT00772577	COMPLETED	Hypertension	Novartis	2008-08	PHASE4
NCT00813722	UNKNOWN	Blood Pressure	University of Sao Paulo	1999-03	PHASE4
NCT00605202	COMPLETED	Hypokalemia	University of Oulu	2008-02	PHASE4
NCT00263393	COMPLETED	Myocardial Infarction; Angina Pectoris; Cerebrovascular Accidents; Diabetes Mellitus	The George Institute	2005-12	PHASE4
NCT00424801	TERMINATED	Microvascular Angina; Hypertension	University of Aarhus	2007-01
NCT00443612	COMPLETED	Hypertension	Sanofi	2006-09	PHASE4
NCT00775814	COMPLETED	Obesity; Hypertension	Takeda	2006-10	PHASE4
NCT02276378	COMPLETED	Healthy	Boehringer Ingelheim	2008-07	PHASE1
NCT00386607	COMPLETED	Hypertension	Novartis	2006-10	PHASE3
NCT00700583	COMPLETED	Nocturia	Seoul National University Hospital	2008-05
NCT00430950	COMPLETED	Essential Hypertension	Daiichi Sankyo	2007-02	PHASE3
NCT00687206	COMPLETED	Hypertension; Ventricular Remodeling; Erectile Dysfunctions	Federico II University	2008-03	PHASE4
NCT00441350	COMPLETED	Hypertension	Menarini Group	2007-07	PHASE3
NCT00671424	COMPLETED	Type 2 Diabetes Mellitus; Diabetes Mellitus, Type 2	GlaxoSmithKline	2008-03	PHASE1
NCT00311155	COMPLETED	Essential Hypertension	Sankyo Pharma Gmbh	2006-03	PHASE4
NCT00607035	COMPLETED	Hypertension	Jichi Medical University	2006-05	PHASE4
NCT00402103	COMPLETED	Hypertension	Novartis	2006-11	PHASE3
NCT00412932	COMPLETED	Hypertension	Daiichi Sankyo	2006-12	PHASE4
NCT00430508	COMPLETED	Essential Hypertension	Daiichi Sankyo	2007-02	PHASE3
NCT00142584	COMPLETED	Hypertension	Mylan Bertek Pharmaceuticals	2005-08	PHASE3
NCT00368277	COMPLETED	Hypertension	Novartis Pharmaceuticals	2006-09	PHASE3
NCT00547300	TERMINATED	Hypertension	Forest Laboratories	2007-10-31	PHASE3
NCT00546052	COMPLETED	Hypertension; Metabolic Disorder	Organon and Co	2005-09-01	PHASE3
NCT00434967	COMPLETED	Hypertension	AstraZeneca	2007-01	PHASE3
NCT00170950	TERMINATED	Hypertension	Novartis	2003-10	PHASE3
NCT00523744	COMPLETED	Hypertension	Novartis	2007-07	PHASE3
NCT00396656	COMPLETED	Hypertension	Novartis	2005-12	PHASE3
NCT00400777	COMPLETED	Hypertension	Novartis	2006-08	PHASE4
NCT00439738	COMPLETED	Hypertension	Novartis Pharmaceuticals	2006-12	PHASE4
NCT00403481	COMPLETED	Hypertension	Daiichi Sankyo	2006-11	PHASE4
NCT00447603	TERMINATED	Hypertension	Organon and Co	2007-05-24	PHASE3
NCT00425997	COMPLETED	Hypertension	Novartis	2006-12	PHASE4
NCT00430638	COMPLETED	Hypertension	Daiichi Sankyo	2006-12	PHASE4
NCT00872781	COMPLETED	Healthy	Ranbaxy Laboratories Limited	2007-10
NCT00171054	COMPLETED	Hypertension	Novartis	2003-09	PHASE4
NCT01712139	COMPLETED	Hypertension	Roxane Laboratories	2007-09
NCT00487123	COMPLETED	Hypertension	Novartis		PHASE4
NCT00338936	COMPLETED	Hypertension	Novartis	2006-05	PHASE3
NCT01712126	COMPLETED	Hypertension	Roxane Laboratories	2007-09
NCT00171132	COMPLETED	Hypertension	Novartis	2004-08	PHASE4
NCT00326768	COMPLETED	Hypertension	Boehringer Ingelheim	2006-05	PHASE3
NCT00383929	COMPLETED	Hypertension	AstraZeneca	2006-09	PHASE3
NCT00872586	COMPLETED	Essential Hypertension	Daiichi Sankyo	2006-08	PHASE3
NCT00890591	COMPLETED	Essential Hypertension	Daiichi Sankyo	2006-08	PHASE4
NCT00219102	COMPLETED	Hypertension; Diabetes	Novartis	2005-06	PHASE3
NCT00398541	COMPLETED	Hypertension	Organon and Co	2005-03-01	PHASE3
NCT00354991	COMPLETED	Hypertension	Merck Sharp & Dohme LLC	2006-06-01	PHASE3
NCT00821574	COMPLETED	Hypertension, Dyslypidaemia	Novartis	2005-07	PHASE4
NCT00355589	COMPLETED	Hypertension; Blood Pressure, High	Pfizer	2006-07	PHASE3
NCT00289887	COMPLETED	Hypertension	Organon and Co	2006-02	PHASE3
NCT00110422	COMPLETED	Metabolic Syndrome; Hypertension	Bristol-Myers Squibb	2005-11	PHASE4
NCT00267943	COMPLETED	Hypertension	Boehringer Ingelheim	2006-01	PHASE3
NCT00327145	COMPLETED	Hypertension	Novartis	2006-03	PHASE3
NCT00360178	COMPLETED	Hypertension	Novartis	2006-07	PHASE3
NCT01019590	COMPLETED	Healthy	Mylan Pharmaceuticals Inc	2006-11	PHASE1
NCT01020214	COMPLETED	Healthy	Mylan Pharmaceuticals Inc	2006-11	PHASE1
NCT00449111	TERMINATED	Hypertension	Organon and Co	2006-03-13	PHASE3
NCT00311740	COMPLETED	Hypertension	Novartis	2006-03	PHASE3
NCT00146341	COMPLETED	Hypertension	Boehringer Ingelheim	2005-04	PHASE3
NCT00185120	COMPLETED	Hypertension	Daiichi Sankyo	2005-09	PHASE4
NCT00171561	COMPLETED	Hypertension	Novartis	2003-03	PHASE4
NCT00280540	COMPLETED	Hypertension	Novartis	2005-12	PHASE4
NCT00257491	COMPLETED	Hypertension	Boehringer Ingelheim	2005-11	PHASE3
NCT00239369	COMPLETED	Hypertension	Boehringer Ingelheim	2005-10	PHASE3
NCT00400218	COMPLETED	Hypertension	Organon and Co	2005-09-01	PHASE3
NCT00273299	COMPLETED	Hypertension	Novartis	2005-11	PHASE3
NCT00168779	COMPLETED	Hypertension	Boehringer Ingelheim	2005-09	PHASE4
NCT00776646	COMPLETED	Healthy	Ranbaxy Laboratories Limited	2006-05
NCT00250562	COMPLETED	Hypertension	Novartis	2005-10	PHASE3
NCT02336607	COMPLETED	Hypertension	AstraZeneca	2005-12
NCT00247910	COMPLETED	Hypertension	University of British Columbia	2001-10
NCT00234858	COMPLETED	Hypertension; Metabolic Syndrome	Abbott	2004-03	PHASE4
NCT00232882	COMPLETED	Hypertension	Institut de Recherches Cliniques de Montreal	2003-12	PHASE4
NCT00170937	COMPLETED	METABOLIC SYNDROME; HYPERTENSION; PRE-HYPERTENSION	Novartis	2004-11	PHASE4
NCT00282178	COMPLETED	Hypertension; Obesity	Umeå University	2005-04	PHASE2
NCT00219063	COMPLETED	Hypertension	Novartis	2005-02	PHASE3
NCT00214825	COMPLETED	Diabetes Mellitus; Endothelial Dysfunction; Albuminuria	Brigham and Women's Hospital	2003-08
NCT00157963	COMPLETED	Essential Hypertension	Organon and Co	2005-02-05	PHASE4
NCT00171405	COMPLETED	Hypertension	Novartis	2005-06	PHASE3
NCT00638482	TERMINATED	Dent's Disease; Nephrolithiasis	Assistance Publique - Hôpitaux de Paris	2003-07	PHASE2; PHASE3
NCT00277472	COMPLETED	Hypertension	Novartis	2005-11	PHASE4
NCT00649324	COMPLETED	Healthy	Mylan Pharmaceuticals Inc	2005-10	EARLY_PHASE1
NCT00219037	COMPLETED	Hypertension	Novartis	2004-06	PHASE3
NCT00144222	COMPLETED	Hypertension	Boehringer Ingelheim	2005-01	PHASE3
NCT00772499	COMPLETED	Hypertension	Daiichi Sankyo	2002-11	PHASE4
NCT00170989	COMPLETED	Hypertension	Novartis	2004-09	PHASE3
NCT00872235	COMPLETED	Healthy	Ranbaxy Laboratories Limited	2005-06
NCT00307060	COMPLETED	Mild to Severe Hypertension	Organon and Co	2004-12-01	PHASE3
NCT00185172	COMPLETED	Essential Hypertension	Sankyo Pharma Gmbh	2002-01	PHASE3
NCT00219024	COMPLETED	Hypertension	Novartis	2004-08	PHASE3
NCT00153049	COMPLETED	Hypertension	Boehringer Ingelheim	2004-06	PHASE2
NCT00171535	COMPLETED	Hypertension	Novartis	2004-10	PHASE3
NCT00171015	COMPLETED	Hypertension	Novartis	2004-12	PHASE3
NCT00751751	COMPLETED	Essential Hypertension	Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company	2003-06	PHASE3
NCT00241007	COMPLETED	Hypertension	Novartis	2003-12	PHASE3
NCT01102478	COMPLETED	Hypertension	Roxane Laboratories	2005-02
NCT00133185	COMPLETED	Hypertension	Boehringer Ingelheim	2004-03	PHASE3
NCT01102465	COMPLETED	Hypertension	Roxane Laboratories	2005-02
NCT00239538	COMPLETED	Hypertension; Diabetes Mellitus, Type 2	Boehringer Ingelheim	2003-01	PHASE4
NCT00171782	COMPLETED	HYPERTENSION	Novartis	2004-02	PHASE4
NCT00778674	COMPLETED	Healthy	Ranbaxy Laboratories Limited	2004-10
NCT00778726	COMPLETED	Healthy	Ranbaxy Laboratories Limited	2004-09
NCT00751829	COMPLETED	Isolated Systolic Hypertension	Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company	2003-07	PHASE3
NCT00642096	COMPLETED	High Blood Pressure (Hypertension).	AstraZeneca	2003-06	PHASE3
NCT00140959	COMPLETED	Hypertension	Organon and Co	2003-02-01	PHASE4
NCT00847834	COMPLETED	Hypertension	Sanofi	2003-12	PHASE4
NCT00240448	COMPLETED	Hypertension	Boehringer Ingelheim	2003-09	PHASE4
NCT00953680	COMPLETED	Hypertension	Organon and Co	2004-04	PHASE1
NCT03276598	COMPLETED	Hypertension; Pharmacogenetics	Helsinki University Central Hospital	1999-11-25	PHASE4
NCT01149473	COMPLETED	Healthy	Teva Pharmaceuticals USA	2004-03	PHASE1
NCT00240474	COMPLETED	Hypertension	Boehringer Ingelheim	2002-12	PHASE4
NCT01149486	COMPLETED	Healthy	Teva Pharmaceuticals USA	2004-01	PHASE1
NCT00834067	COMPLETED	Healthy	Teva Pharmaceuticals USA	2003-10	PHASE1
NCT00835042	COMPLETED	Healthy	Teva Pharmaceuticals USA	2003-10	PHASE1
NCT00649441	COMPLETED	Healthy	Mylan Pharmaceuticals Inc	2003-08	PHASE1
NCT00648011	COMPLETED	Healthy	Mylan Pharmaceuticals Inc	2003-08	PHASE1
NCT00274638	COMPLETED	Hypertension	Boehringer Ingelheim	2002-07	PHASE4
NCT00778713	COMPLETED	Healthy	Ranbaxy Laboratories Limited	2003-03
NCT00777972	COMPLETED	Healthy	Ranbaxy Laboratories Limited	2003-03
NCT00649233	COMPLETED	Healthy	Mylan Pharmaceuticals Inc	2003-01	PHASE1
NCT00649688	COMPLETED	Healthy	Mylan Pharmaceuticals Inc	2003-01	PHASE1
NCT00649597	COMPLETED	Healthy	Mylan Pharmaceuticals Inc	2002-11	PHASE1
NCT00649038	COMPLETED	Healthy	Mylan Pharmaceuticals Inc	2002-12	PHASE1
NCT00092209	COMPLETED	Hypertension	Organon and Co	2002-04	PHASE3
NCT00480805	COMPLETED	Type 2 Diabetes Mellitus; Hypertension	Organon and Co	2001-08-08	PHASE3
NCT02172586	COMPLETED	Hypertension	Boehringer Ingelheim	2000-01	PHASE4
NCT03921736	COMPLETED	Hypertension; Hyperuricemia; Menopause	Anna Posadzy-Małaczyńska	2000-01-10	PHASE4
NCT02175355	COMPLETED	Hypertension	Boehringer Ingelheim	1999-10	PHASE3
NCT02177500	COMPLETED	Hypertension	Boehringer Ingelheim	2000-01	PHASE3
NCT02177487	COMPLETED	Hypertension	Boehringer Ingelheim	1999-06	PHASE3
NCT02187523	COMPLETED	Healthy	Boehringer Ingelheim	1999-10	PHASE1
NCT02177422	COMPLETED	Hypertension	Boehringer Ingelheim	1998-06	PHASE3
NCT02177435	COMPLETED	Hypertension	Boehringer Ingelheim	1999-02	PHASE3
NCT02183701	COMPLETED	Hypertension	Boehringer Ingelheim	1998-04	PHASE3
NCT00886600	COMPLETED	Hypertension	Merck Sharp & Dohme LLC	1991-05	PHASE3
NCT00000525	COMPLETED	Cardiovascular Diseases; Death, Sudden, Cardiac; Heart Arrest; Heart Diseases; Hypertension	University of California, San Francisco	1986-07	PHASE3
NCT01218724	COMPLETED	Healthy	Torrent Pharmaceuticals Limited		PHASE1
NCT00160160	COMPLETED	Hypertension; Type 2 Diabetes	Solvay Pharmaceuticals	2004-10
NCT00367094	COMPLETED	Hypertension	Novartis	2006-07	PHASE3
NCT00374855	COMPLETED	Mild Hypertension	Eli Lilly and Company	2006-09	PHASE2
NCT00394394	COMPLETED	Hypertension	Hospital de Clinicas de Porto Alegre	2005-02	PHASE2
NCT01218711	COMPLETED	Healthy	Torrent Pharmaceuticals Limited		PHASE1
NCT00139698	COMPLETED	Essential Hypertension	Pfizer	2005-09	PHASE3
NCT00263003	COMPLETED	Hypertension	Sanofi	2005-06	PHASE3
NCT00185185	COMPLETED	Essential Hypertension; Atherosclerotic Cardiovascular Disease	Sankyo Pharma Gmbh	2001-11	PHASE3
NCT00651287	COMPLETED	Hypertension	Pfizer	2002-12	PHASE4
NCT00089713	TERMINATED	Hypertension	Synvista Therapeutics, Inc	2004-03	PHASE2
NCT00306696	COMPLETED	Diabetes Mellitus	GlaxoSmithKline	2002-10	PHASE4
NCT00548067	COMPLETED	Hypertension	Novartis	2007-09	PHASE3
NCT00185068	COMPLETED	Hypertension	Daiichi Sankyo	2004-03	PHASE4
NCT00990301	COMPLETED	Healthy	Paddock Laboratories, Inc.		PHASE1
NCT00264212	COMPLETED	Hypertension	Sanofi	2004-08	PHASE4
NCT00426478	COMPLETED	Hypertension	Novartis	2006-11	PHASE4
NCT00220233	COMPLETED	Essential Hypertension	Sankyo Pharma Gmbh	2005-04	PHASE3
NCT00369538	SUSPENDED	Proteinuria; Hypertension; End Stage Renal Disease	University Hospital, Strasbourg, France	2006-08	PHASE4
NCT00133692	COMPLETED	Hypertension; Coronary Artery Disease	University of Florida	1997-09	PHASE4

(data from https://clinicaltrials.gov, updated on 2025-06-13)

Check the Hydrochlorothiazide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Hydrochlorothiazide selectively binds to and inhibits the sodium-chloride cotransporter (NCC) in the renal distal convoluted tubule, blocking luminal sodium and chloride ion reabsorption. This inhibition impairs osmotic fluid retention and promotes diuresis and natriuresis, ultimately decreasing intravascular volume to lower blood pressure in clinical settings such as essential hypertension and kidney insufficiency.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).