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LDH Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S6871 Sodium oxamate Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. This compound induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.
Cell Death Discov, 2026, 12(1)146
Adv Sci (Weinh), 2025, 12(8):e2411943
Nucleic Acids Res, 2025, 53(17)gkaf882
S0108 AZ-33 AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 0.5 μM. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.
Frontiers in Molecular Biosciences, January 12, 2022, 806650
Research Square (Preprint), 2025, nan
Frontiers in Molecular Biosciences, 2022, 806650
S8928 FX-11 (LDHA Inhibitor FX11) FX-11(LDHA Inhibitor FX11) is a potent inhibitor of lactate dehydrogenase A (LDHA)) with IC50 of 49.27 μM in BxPc-3 cells.
Theranostics, 2025, 15(7):3055-3075
Cell Death Dis, 2025, 16(1):574
Cell Metab, 2024, S1550-4131(24)00415-7
S9606 Galloflavin Galloflavin (NSC 107022) is a novel inhibitor of lactate dehydrogenasee (LDH) with Ki values of 5.46 μM and 15.06 μM for LDH-A and LDH-B, respectively.
J Virol, 2024, 98(1):e0167023
Journal of Virology, 2024, e01670-23
Journal of Virology, 2024, e0167023
E4772 LDHA-IN-3 LDHA-IN-3, a selenobenzene derivative, is a potent noncompetitive inhibitor of Lactate Dehydrogenase A (LDHA), with an IC50 of 145.2 nM. It exhibits significant anti-tumor activity, effectively reducing LDHA activity and lactate production under both normoxic and hypoxic conditions. It also induces mitochondria-mediated apoptosis through the generation of reactive oxygen species.
E4635New AXKO-0046 hydrochloride AXKO-0046 hydrochloride is an indole-derived, selective LDHB inhibitor that acts through an uncompetitive mechanism, with an EC50 of 42 nM. It binds an allosteric site distinct from the catalytic active site and shows selectivity over LDHA.
E3731 Chinese Gallnut Extract Chinese Gallnut Extract is obtained from Melaphis chinensis gallnut, which is the most potent inhibitor of human Lactate dehydrogenase (LDH)-A in the high-throughput screening study of 905 natural products.
E6631New Oxamic acid Oxamic acid (Oxamate) is a classical inhibitor of lactate dehydrogenase‑A (LDH‑A) that competitively blocks the conversion of pyruvate to lactate. It also induces G2/M arrest and apoptosis, and increases radiosensitivity in nasopharyngeal carcinoma cells.
S6675 (R)-GNE-140 (R)-GNE-140 is an inhibitory agent for LDHA, LDHB, and LDHC, with IC50 values ​​of 3 nM and 5 nM for LDHA and LDHB, respectively. (R)-GNE-140 is 18 times more potent than its S isomer.
J Clin Invest, 2024, 134(17)e177606
Nature Communications, 2024, 90
J Mol Cell Biol, 2024, mjae056
S8590 GSK2837808A GSK2837808A is a selective LDHA (lactate dehydrogenase A) inhibitor with IC50 of 2.6 nM and 43 nM for hLDHA and hLDHB, respectively.
Cancer Commun (Lond), 2025, 10.1002/cac2.70036
EMBO Rep, 2025, 10.1038/s44319-025-00573-8
Nat Neurosci, 2022, 25(7):865-875