HMG-CoA Reductase Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S1792	Simvastatin (MK-733)	Simvastatin is a competitive inhibitor of HMG-CoA reductase with K_i of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis.	Nat Metab, 2025, 7(10):2018-2032 Cancer Commun (Lond), 2025, 10.1002/cac2.70036 J Clin Invest, 2025, e190215
S2061	Lovastatin (Mevinolin, MK-803)	Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy.	J Clin Invest, 2025, e190215 Redox Biol, 2025, 84:103693 PLoS Pathog, 2025, 21(10):e1013558
S5715	Atorvastatin	Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy.	Cell, 2025, S0092-8674(25)00751-2 Cell Stem Cell, 2025, S1934-5909(25)00265-6 Pigment Cell Melanoma Res, 2025, 38(3):e70021
S1759	Pitavastatin (NK-104) Calcium	Pitavastatin calcium, a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis.	bioRxiv, 2025, 2025.08.10.669191 Nat Commun, 2024, 15(1):4099 J Immunother Cancer, 2024, 12(11)e009805
S1909	Fluvastatin Sodium	Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.	J Immunother Cancer, 2024, 12(11)e009805 Oncogene, 2022, 41(39):4446-4458 iScience, 2022, 25(10):105068
S2169	Rosuvastatin calcium	Rosuvastatin calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay.	Biochem Pharmacol, 2025, 241:117171 J Immunother Cancer, 2024, 12(11)e009805 JCI Insight, 2024, 9(24)e178535
S2077	Atorvastatin Calcium (CI-981)	Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy.	Journal of Virology, July 27, 2017, e00461-17 J Exp Clin Cancer Res, 2025, 44(1):317 Journal of Experimental & Clinical Cancer Research, 2025, 317
S3036	Pravastatin (CS-514) Sodium	Pravastatin sodium (CS-514) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.	Molecular Pharmaceutics, 2024, 2284-2297 Int J Mol Sci, 2023, 24(7)6500 Biomedicines, 2022, 2123
S4223	Mevastatin	Mevastatin (ML-236B,Compactin) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.	J Immunother Cancer, 2024, 12(11)e009805 ERJ Open Research, 2023, 00495-2022 Nat Cardiovasc Res, 2023, 2(6):550-571
S5713	Pravastatin	Pravastatin(CS-514) is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins.	Journal of Cosmetic Dermatology, June 22, 2022, 534-541 EMBO Reports, 2022, e53373 EMBO Rep, 2022, e53373
E6038	Pitavastatin	Pitavastatin (NK-104) is a highly potent inhibitor of HMG-CoA reductase with an IC50 of 6.8 nmol/L, which significantly enhances LDL receptor activity and lowers LDL cholesterol (LDL-C) levels. It also inhibits cholesterol synthesis in vitro and has the potential to manage hypercholesterolemia and reducing cardiovascular risk.	Nat Commun, 2025, 16(1):5360 Nature Communications, 2025, 5360 Biochem Biophys Res Commun, 2025, 742:151094
E4981	Fluvastatin	Fluvastatin is a competitive inhibitor of HMG-CoA reductase with an IC50 value of 40 and 100 nM in human liver microsomes. This compound also exerts cytoprotective effects against oxidative stress through the Nrf2-dependent antioxidant pathway.	Pharmacology, 2025, nan JCI Insight, 2024, 9(24)e178535 BMC Cancer, 2022, 282
S8302	SR-12813	SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.	Front Pharmacol, 2024, 15:1488367 Evid Based Complement Alternat Med, 2021, 2021:4358163 Canadian Journal of Physiology and Pharmacology, 2019 Jan, 15-22
S2664	Clinofibrate	Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood.	Carcinogenesis, December 2020, 1724–1734 Advanced Science, 2025, e2509574 Carcinogenesis, 2020, 7;bgaa036
E4792	Atorvastatin calcium hydrate	Atorvastatin calcium hydrate (Totalip) is a potent inhibitor of the HMG-CoA reductase . It is used as a potent hypolipidemic agent to reduce the elevated total-cholesterol, low-density lipoprotein (LDL), apolipoprotein B (apo B), and triglyceride (TG) levels, and to increase the high-density lipoprotein cholesterol (HDL-C) level in patients with primary hypercholesterolemia and mixed dyslipidemia.	International Journal of Molecular Sciences, January 2026, 1358 BMC Pharmacology and Toxicology, February 28, 2013, 15 International Journal of Molecular Sciences, 2026, 1358
E4821	Simvastatin acid (ammonium)	Simvastatin acid (Tenivastatin) ammonium is a potent inhibitor of HMG-CoA reductase (HMGCR). This compound also decreases Indoxyl sulfate-induced reactive oxygen species (ROS) production in human cardiomyocytes and regulates the expression of OATP3A1 in these cells.
E1341	Cerivastatin sodium	Cerivastatin sodium, a sodium salt of cerivastatin, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase with Ki of 1.3 nM. It is also a synthetic, enantiomerically pure, pyridine derivative that effectively reduces serum cholesterol levels at microgram doses.
E2286	Dihydrolanosterol	Dihydrolanosterol (24,25-Dihydrolanosterol; Dihydrolanosterin; Lanostenol) inhibits cholesterol biosynthesis by promoting ubiquitination and degradation of HMG CoA reductase.
E2741	7-ketocholesterol	7-Ketocholesterol (7-Oxocholesterol), is a bioactive sterol and prominent cholesterol oxidation product, is a strong inhibitor of HMG-CoA reductase and cytochrome P450 7A1. It enhances oxidative stress, endoplasmic reticulum stress, and apoptosis in macrophages.