Home Metabolism HMG-CoA Reductase

HMG-CoA Reductase Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
E6038 Pitavastatin Pitavastatin (NK-104) is a highly potent inhibitor of HMG-CoA reductase with an IC50 of 6.8 nmol/L, which significantly enhances LDL receptor activity and lowers LDL cholesterol (LDL-C) levels. It also inhibits cholesterol synthesis in vitro and has the potential to manage hypercholesterolemia and reducing cardiovascular risk. 
Nat Commun, 2025, 16(1):5360
Nature Communications, 2025, 5360
Biochem Biophys Res Commun, 2025, 742:151094
E4981 Fluvastatin Fluvastatin is a competitive inhibitor of HMG-CoA reductase with an IC50 value of 40 and 100 nM in human liver microsomes. This compound also exerts cytoprotective effects against oxidative stress through the Nrf2-dependent antioxidant pathway.
Pharmacology, 2025, nan
JCI Insight, 2024, 9(24)e178535
BMC Cancer, 2022, 282
S8302 SR-12813 SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.
Front Pharmacol, 2024, 15:1488367
Evid Based Complement Alternat Med, 2021, 2021:4358163
Canadian Journal of Physiology and Pharmacology, 2019 Jan, 15-22
S2664 Clinofibrate Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood.
Carcinogenesis, December 2020, 1724–1734
Advanced Science, 2025, e2509574
Carcinogenesis, 2020, 7;bgaa036
E4792 Atorvastatin calcium hydrate Atorvastatin calcium hydrate (Totalip) is a potent inhibitor of the HMG-CoA reductase . It is used as a potent hypolipidemic agent to reduce the elevated total-cholesterol, low-density lipoprotein (LDL), apolipoprotein B (apo B), and triglyceride (TG) levels, and to increase the high-density lipoprotein cholesterol (HDL-C) level in patients with primary hypercholesterolemia and mixed dyslipidemia.
International Journal of Molecular Sciences, January 2026, 1358
BMC Pharmacology and Toxicology, February 28, 2013, 15
International Journal of Molecular Sciences, 2026, 1358
E4821 Simvastatin acid (ammonium) Simvastatin acid (Tenivastatin) ammonium is a potent inhibitor of HMG-CoA reductase (HMGCR). This compound also decreases Indoxyl sulfate-induced reactive oxygen species (ROS) production in human cardiomyocytes and regulates the expression of OATP3A1 in these cells.
E1341 Cerivastatin sodium Cerivastatin sodium, a sodium salt of cerivastatin, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase with Ki of 1.3 nM. It is also a synthetic, enantiomerically pure, pyridine derivative that effectively reduces serum cholesterol levels at microgram doses.
E2286 Dihydrolanosterol Dihydrolanosterol (24,25-Dihydrolanosterol; Dihydrolanosterin; Lanostenol) inhibits cholesterol biosynthesis by promoting ubiquitination and degradation of HMG CoA reductase.
E2741 7-ketocholesterol 7-Ketocholesterol (7-Oxocholesterol), is a bioactive sterol and prominent cholesterol oxidation product, is a strong inhibitor of HMG-CoA reductase and cytochrome P450 7A1. It enhances oxidative stress, endoplasmic reticulum stress, and apoptosis in macrophages.