GPX

Other Immunology & Inflammation Related Inhibitors

CXCR AhR STING COX IL Receptor gp120/CD4 NOD NADPH-oxidase ROS Nrf2

Cat.No.	Product Name	Information	Product Use Citations
S8155	RSL3	RSL3 ((1S,3R)-RSL3) is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis.	Rockefeller University Digital Commons @ RU, 221, 670 Exp Cell Res, 2026, 454(1):114825 Nature, 2025, 10.1038/s41586-025-09222-5
S4452	ML162	ML162 is a covalent inhibitor of cellular phospholipid glutathione peroxidase (GPX-4) that induces ferroptosis.	Nat Commun, 2025, 16(1):1982 J Adv Res, 2025, S2090-1232(25)00045-1 Cell Death Dis, 2025, 16(1):614
E6610^New	GPX4-IN-5	GPX4-IN-5 covalently inhibits GPX4 with an IC50 of 0.12 μM. This compound induces ferroptosis and exhibits anti-tumor activity. It has potential applications in triple-negative breast cancer (TNBC) research.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S8155

RSL3

RSL3 ((1S,3R)-RSL3) is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis.

Rockefeller University Digital Commons @ RU, 221, 670

Exp Cell Res, 2026, 454(1):114825

Nature, 2025, 10.1038/s41586-025-09222-5

S4452

ML162

ML162 is a covalent inhibitor of cellular phospholipid glutathione peroxidase (GPX-4) that induces ferroptosis.

Nat Commun, 2025, 16(1):1982

J Adv Res, 2025, S2090-1232(25)00045-1

Cell Death Dis, 2025, 16(1):614

E6610^New

GPX4-IN-5

GPX4-IN-5 covalently inhibits GPX4 with an IC50 of 0.12 μM. This compound induces ferroptosis and exhibits anti-tumor activity. It has potential applications in triple-negative breast cancer (TNBC) research.