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Diquafosol Tetrasodium P2 Receptor agonist

Name: Diquafosol Tetrasodium
Brand: Selleck Chemicals
SKU: S6592
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S6592

Diquafosol Tetrasodium (INS-365), a P2Y2 receptor agonist, is a pharmaceutical drug for the treatment of dry eye disease.

Diquafosol Tetrasodium P2 Receptor agonist Chemical Structure

Quality Control

Batch: Purity: 99.84%

99.84

Related Targets	Adrenergic Receptor AChR 5-HT Receptor COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE)
Other P2 Receptor Inhibitors	A-438079 Hydrochloride A-804598 MRS 2578 AF-353 A-740003 5-BDBD Aurintricarboxylic acid A-317491 Gefapixant JNJ-47965567

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5mg/ml (5.69mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.71mg/ml (0.81mM)	Taking the 1 mL working solution as an example, add 50 μL of 14.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	878.23	Formula	C₁₈H₂₂N₄Na₄O₂₃P₄	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	211427-08-6	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	INS-365			SMILES	C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OCC3C(C(C(O3)N4C=CC(=O)NC4=O)O)O)O)O.[Na+].[Na+].[Na+].[Na+]

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	P2Y2 receptor
References	[1] https://pubmed.ncbi.nlm.nih.gov/14680452/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-04-30)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06903884	RECRUITING	Vernal Keratoconjunctivitis	The University of Hong Kong	2026-02-09	PHASE3
NCT07397949	NOT_YET_RECRUITING	Dry Eye Disease (DED); Cataract	Samsung Medical Center	2026-03	PHASE4
NCT06852105	NOT_YET_RECRUITING	Dry Eye; Tear Break-Up Time	He Eye Hospital	2025-02-28
NCT07097922	NOT_YET_RECRUITING	Dry Eye	He Eye Hospital	2025-08-01
NCT07397936	COMPLETED	Dry Eye Disease (DED); Cataract	Samsung Medical Center	2024-08-01	PHASE4
NCT06537349	UNKNOWN	Dry Eye	He Eye Hospital	2024-08-15

Tech Support

Handling Instructions

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