CAS No. 211427-08-6

Batch: Purity:99.84
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Diquafosol Tetrasodium Chemical Structure
Chemical Structure
Check the Diquafosol Tetrasodium product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name tetrasodium;[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate
CAS Number 211427-08-6
Molecular Formula

C18H22N4Na4O23P4
Molecular Weight (MW) 878.23
SMILES C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OCC3C(C(C(O3)N4C=CC(=O)NC4=O)O)O)O)O.[Na+].[Na+].[Na+].[Na+]
InChIKey OWTGMPPCCUSXIP-FNXFGIETSA-J

Ordering Information

Biological Activity

Diquafosol tetrasodium is a purinergic P2Y2 receptor agonist developed for the treatment of dry eye disease. Activation of P2Y2 receptors by diquafosol stimulates intracellular calcium mobilization and activates downstream signaling pathways that promote fluid secretion from corneal and conjunctival epithelial cells. In addition, P2Y2 receptor stimulation drives mucin release from conjunctival goblet cells, thereby enhancing tear film stability and restoring ocular surface hydration. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 100 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.