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p300/CBP

Other Epigenetics Related Inhibitors

Histone Methyltransferase BET DNA Methyltransferase Histone Demethylase Histone Acetyltransferase MicroRNA NSD EZH1 RNA Methyltransferase SF3B
Cat.No. Product Name Information Product Use Citations Product Validations
S9667 Inobrodib (CCS-1477) Inobrodib (CCS1477; CBP-IN-1; CBP/p300-IN-4）is a potent and selective inhibitor of p300/CBP bromodomain. CCS1477 works by inhibiting the expression and function of the androgen receptor (AR), as well as inhibiting c-Myc.
Nat Genet, 2025, 57(10):2468-2481
Nat Commun, 2025, 16(1):4133
PLoS Pathog, 2025, 21(9):e1013073
S8740 A-485 A-485 is a potent, selective and drug-like p300/CBP catalytic inhibitor with an IC50 of 0.06 μM for p300 HAT. It is selective over BET bromodomain proteins and >150 non-epigenetic targets.
Nat Genet, 2025, 57(10):2468-2481
Cancer Discov, 2025, 15(2):382-400
Nat Cell Biol, 2025, 10.1038/s41556-025-01658-1
S8968 PRI-724 (Foscenvivint) Foscenvivint (PRI-724) is a potent and specific inhibitor that disrupts the interaction of β-catenin and CBP.
Cancer Discov, 2025, 10.1158/2159-8290.CD-25-0629
Cell Death Dis, 2025, 16(1):466
Biomed Pharmacother, 2025, 188:118225
S2662 ICG-001 ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to CREB-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. ICG-001 induces apoptosis.
Cancer Discov, 2025, 10.1158/2159-8290.CD-25-0629
Adv Sci (Weinh), 2025, 12(40):e05702
Cell Rep Med, 2025, 6(2):101927
Verified customer review of ICG-001
S1848 Curcumin Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM）and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.
J Biol Chem, 2025, 301(7):110305
Mol Pain, 2025, 21:17448069251323668
BMC Immunol, 2025, 26(1):67
Verified customer review of Curcumin
S7256 SGC-CBP30 SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively.
Mol Cell, 2025, 85(8):1525-1542.e10
Cell Death Dis, 2025, 16(1):193
Cell Rep, 2025, 44(4):115523
Verified customer review of SGC-CBP30
S7582 Anacardic Acid Anacardic Acid (6-pentadecylsalicylic Acid) is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity, prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.
Sci Adv, 2025, 11(9):eadq2881
J Transl Med, 2024, 22(1):995
Int J Mol Sci, 2024, 25(17)9600
Verified customer review of Anacardic Acid
S8190 CPI-637 CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor with IC50 values of 0.03 μM and 0.051μM for CBP and EP300 respectively in TR-FRET assay. It is highly selective against other bromodomains, displaying substantial biochemical activity only against BRD9.
Mol Cell Proteomics, 2023, 22(3):100504
Acta Pharmacol Sin, 2019, 10.1038/s41401-019-0237-5
E1348 E7386 E-7386 is a selective inhibitor which inhibits interaction between CBP/beta-catenin with IC50 value of 0.0484 μM in HEK293 cells.
Adv Sci (Weinh), 2024, 11(35):e2308417
Cell Rep, 2024, 43(8):114532
S6758 I-CBP112 I-CBP112 is a potent and selective CBP/p300 inhibitor with dissociation constant (KD) of 151 ± 6 nM and 167 ± 8 nM for CBP and p300, respectively.
Hepatology, 2021, 10.1002/hep.32245